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Synthesis and biological effects of naphthalene-chalcone derivatives

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Abstract

In this paper, 21 naphthalene-chalcone derivatives were synthesized and their biological effects were evaluated. The results showed that compounds 2a–2u displayed clear antidepressant activity at 30 mg/kg in the forced swimming test. Compounds 2h, 2o, 2t, and 2u exhibited a good antidepressant effect in the forced swimming test and tail suspension test at 30 mg/kg. Compounds 2h, 2o, 2t, and 2u but had no effect on locomotor activity in the open-field test in mice. In addition, the most antidepressant activity of compound 2o is likely mediated by increased serotonin and norepinephrine levels in central nervous system. Compounds 2a–2u also showed the analgesic and anti-inflammatory effects at 30 mg/kg.

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Acknowledgements

This research was funded by the National Natural Science Foundation of China (No. 81760207 and 81560149) and Zhejiang Province Public Technology Application Project of China (No. LGJ20H090001) and Research project of laboratory work in Colleges and universities of Zhejiang Province (No. YB201946). We thank Arshad Makhdum, PhD, from Liwen Bianji, Edanz Group China (www.liwenbianji.cn/ac), for editing the English text of a draft of this manuscript.

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Authors and Affiliations

  1. Donghai Science and Technology College, Zhejiang Ocean University, Zhoushan, 316000, Zhejiang, PR China

    Qing-Hao Jin

  2. Hailisheng Pharmaceutical Co Ltd, Zhoushan, 316000, Zhejiang, PR China

    Hong-Hai Chen & Wen-Bo Chen

  3. Food and Pharmacy College, Zhejiang Ocean University, Zhoushan, 316022, Zhejiang, PR China

    Zhi-Yang Fu & Li-Ping Guan

  4. College of Medicine, Jiaxing University, Zhejiang, 314001, Jiaxing, PR China

    Hai-Ying Jiang

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Jin, QH., Chen, HH., Chen, WB. et al. Synthesis and biological effects of naphthalene-chalcone derivatives. Med Chem Res 29, 877–886 (2020). https://doi.org/10.1007/s00044-020-02525-4

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