Abstract
A palladium(II) complex, [Pd(L)Cl] (1) with a new ONS donor azo–thioether ligand (L) (where L = 2,4-dihydroxy-5-((2-(methylthio)phenyl)diazenyl)(phenyl)(phenyl)methanone) is successfully synthesized. The ligand and complex are thoroughly characterized by several spectroscopic techniques. The geometry of the complex is confirmed by single-crystal X-ray analysis. Electronic structure and spectral properties are interpreted by DFT and TDDFT calculations. The interaction of the complex with CT DNA was investigated by UV-vis method and binding constant is found to be 5.42 × 104 M−1. Competitive binding titration with ethidium bromide (EB) by fluorescence titration method was carried out to understand the efficiency of the complex to displace EB from EB-DNA complex. From fluorescence titration Stern-Volmer dynamic quenching constants, Ksv was calculated and is found to be 4.15 × 104 M−1. Cyclic voltammogram of the complex exhibits significant shifting of the reduction couple to the negative potential region and decrease in current height in the presence of CT DNA.
Graphic Abstract
SYNOPSIS A palladium(II) complex, [Pd(L)Cl] (1) with a new ONS donor azo–thioether ligand (L) (where L = 2,4-dihydroxy-5-((2-(methylthio)phenyl)diazenyl)(phenyl)(phenyl)methanone) is successfully synthesized and characterized. The geometry of the complex is confirmed by single-crystal X-ray analysis. Electronic structure and spectral properties are interpreted by DFT and TDDFT calculations. The interaction of the complex with CT DNA is investigated by UV-vis, fluorescence and cyclic voltammetric method.
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Financial support received from the Science and Engineering Research Board (SERB) (No. EEQ/2018/000266), New Delhi, India is gratefully acknowledged. R. Naskar is thankful to UGC, New Delhi, India for fellowships.
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JANA, S., NASKAR, R., MANNA, C.K. et al. Synthesis, characterization, X-ray structure and DNA binding study of palladium(II) complex with new thioether containing ONS donor ligand. J Chem Sci 132, 64 (2020). https://doi.org/10.1007/s12039-020-01763-8
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DOI: https://doi.org/10.1007/s12039-020-01763-8