Abstract
Older adults are the fastest growing segment of the population and surgical procedures in this group increase each year. Chronic post-surgical pain is an important consideration in the older adult as it affects recovery, physical functioning, and overall quality of life. It is increasingly recognized as a public health issue but there is a need to improve our understanding of the disease process as well as the appropriate treatment and prevention. Frailty, delirium, and cognition influence post-operative outcomes in older adults and have been implicated in the development of chronic post-surgical pain. Further research must be conducted to fully understand the role they play in the occurrence of chronic post-surgical pain in the older adult. Additionally, careful attention must be given to the physiologic, cognitive, and comorbidity differences between the older adult and the general population. This is critical for elucidating the proper chronic post-surgical pain treatment and prevention strategies to ensure that the older adult undergoing surgical intervention will have an appropriate and desirable post-operative outcome.
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Hall MJ, Schwartzman A, Zhang J, Liu X. Ambulatory surgery data from hospitals and ambulatory surgery centers: United States, 2010. Natl Health Stat Rep. 2017;102:1–15.
National Hospital Discharge Survey. Number of all-listed procedures for discharges from short-stay hospitals, by procedure category and Age: United States, 2010. 2010. https://www.cdc.gov/nchs/data/nhds/4procedures/2010pro4_numberprocedureage.pdf. Accessed 10 Apr 2020.
Macrae WA. Chronic post-surgical pain: 10 years on. Br J Anaesth. 2008;101:77–86.
Kehlet H, Jensen TS, Woolf CJ. Persistent postsurgical pain: risk factors and prevention. Lancet. 2006;367:1618–25.
Wang L, Guyatt GH, Kennedy SA, Romerosa B, Kwon HY, Kaushal A, et al. Predictors of persistent pain after breast cancer surgery: a systematic review and meta-analysis of observational studies. CMAJ. 2016;188:E352–E361361.
Gan TJ. Poorly controlled postoperative pain: prevalence, consequences, and prevention. J Pain Res. 2017;10:2287–98.
Baker DW. History of the Joint Commission’s pain standards: lessons for today’s prescription opioid epidemic. JAMA. 2017;317:1117–8.
Esses GJ, Liu X, Lin HM, Khelemsky Y, Deiner S. Preoperative frailty and its association with postsurgical pain in an older patient cohort. Reg Anesth Pain Med. 2019;44:695–9.
Campbell AJ, Buchner DM. Unstable disability and the fluctuations of frailty. Age Ageing. 1997;26:315–8.
Lee DH, Buth KJ, Martin B-J, Yip AM, Hirsch GM. Frail patients are at increased risk for mortality and prolonged institutional care after cardiac surgery. Circulation. 2010;121:973–8.
Adams P, Ghanem T, Stachler R, Hall F, Velanovich V, Rubinfeld I. Frailty as a predictor of morbidity and mortality in inpatient head and neck surgery. JAMA Otolaryngol Head Neck Surg. 2013;139:783–9.
Makary MA, Segev DL, Pronovost PJ, Syin D, Bandeen-Roche K, Patel P, et al. Frailty as a predictor of surgical outcomes in older patients. J Am Coll Surg. 2010;210:901–8.
Patel KV, Guralnik JM, Dansie EJ, Turk DC. Prevalence and impact of pain among older adults in the United States: findings from the 2011 National Health and Aging Trends Study. Pain. 2013;154:2649–57.
Helme RD, Gibson SJ. The epidemiology of pain in elderly people. Clin Geriatr Med. 2001;17:417–31.
Thielke S, Sale J, Reid MC. Aging: are these 4 pain myths complicating care? J Fam Pract. 2012;61:666–70.
Institute of Medicine. Relieving pain in America. Washington: National Academies Press; 2011.
Glare P, Aubrey KR, Myles PS. Transition from acute to chronic pain after surgery. Lancet. 2019;393:1537–46.
Werner MU, Kongsgaard UE. Defining persistent post-surgical pain: is an update required? Br J Anaesth. 2014;113:1–4.
Macrae WA. Chronic pain after surgery. Br J Anaesth. 2001;87:88–98.
Poobalan AS, Bruce J, Smith WCS, King PM, Krukowski ZH, Chambers WA. A review of chronic pain after inguinal herniorrhaphy. Clin J Pain. 2003;19:48–544.
Weinrib AZ, Azam MA, Birnie KA, Burns LC, Clarke H, Katz J. The psychology of chronic post-surgical pain: new frontiers in risk factor identification, prevention and management. Br J Pain. 2017;11:169–77.
Chapman CR, Vierck CJ. The transition of acute postoperative pain to chronic pain: an integrative overview of research on mechanisms. J Pain. 2017;18(359):e1–38.
Cregg R, Anwar S, Farquhar-Smith P. Persistent postsurgical pain. Curr Opin Support Palliat Care. 2013;7:144–52.
Treede RD, Rief W, Barke A, Aziz Q, Bennett MI, Benoliel R, et al. A classification of chronic pain for ICD-11. Pain. 2015;156:1003–7.
Lavand’homme P. Transition from acute to chronic pain after surgery. Pain. 2017;158(Suppl 1):S50–S5454.
Wylde V, Hewlett S, Learmonth ID, Dieppe P. Persistent pain after joint replacement: prevalence, sensory qualities, and postoperative determinants. Pain. 2011;152:566–72.
Hinrichs-Rocker A, Schulz K, Järvinen I, Lefering R, Simanski C, Neugebauer EAM. Psychosocial predictors and correlates for chronic post-surgical pain (CPSP): a systematic review. Eur J Pain. 2009;13:719–30.
Althaus A, Hinrichs-Rocker A, Chapman R, Becker OA, Lefering R, Simanski C, et al. Development of a risk index for the prediction of chronic post-surgical pain. Eur J Pain. 2012;16:901–10.
Callesen T, Bech K, Kehlet H. Prospective study of chronic pain after groin hernia repair. Br J Surg. 1999;86:1528–31.
Katz J, Jackson M, Kavanagh BP, Sandler AN. Acute pain after thoracic surgery predicts long-term post-thoracotomy pain. Clin J Pain. 1996;12:50–5.
Tasmuth T, Kataja M, Blomqvist C, von Smitten K, Kalso E. Treatment-related factors predisposing to chronic pain in patients with breast cancer: a multivariate approach. Acta Oncol. 1997;36:625–30.
Woolf CJ, Salter MW. Neuronal plasticity: increasing the gain in pain. Science. 2000;288:1765–9.
Katz J, Seltzer Z. Transition from acute to chronic postsurgical pain: risk factors and protective factors. Expert Rev Neurother. 2009;9:723–44.
Bortz WM. A conceptual framework of frailty: a review. J Gerontol A Biol Sci Med Sci. 2002;57:M283–M288288.
Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56:M146–M156156.
Walston JD, Bandeen-Roche K. Frailty: a tale of two concepts. BMC Med. 2015;13:185.
Blyth FM, Rochat S, Cumming RG, Creasey H, Handelsman DJ, Le CDG, et al. Pain, frailty and comorbidity on older men: the CHAMP study. Pain. 2008;140:224–30.
Shega JW, Dale W, Andrew M, Paice J, Rockwood K, Weiner DK. Persistent pain and frailty: a case for homeostenosis. J Am Geriatr Soc. 2012;60:113–7.
Tian X, Wang C, Qiao X, Liu N, Dong L, Butler M, et al. Association between pain and frailty among Chinese community-dwelling older adults: depression as a mediator and its interaction with pain. Pain. 2018;159:306–13.
Wade KF, Lee DM, McBeth J, Ravindrarajah R, Gielen E, Pye SR, et al. Chronic widespread pain is associated with worsening frailty in European men. Age Ageing. 2016;45:268–74.
Lohman MC, Whiteman KL, Greenberg RL, Bruce ML, Edotor D, Kritchevsky S. Incorporating persistent pain in phenotypic frailty measurement and prediction of adverse Health outcomes. J Gerontol A Biol Sci Med Sci. 2017;72:216–22.
Saraiva MD, Suzuki GS, Lin SM, de Andrade DC, Jacob-Filho W, Suemoto CK. Persistent pain is a risk factor for frailty: a systematic review and meta-analysis from prospective longitudinal studies. Age Ageing. 2018;47:785–93.
Resnick NM, Marcantonio ER. How should clinical care of the aged differ? Lancet. 1997;350:1157–8.
Puts MTE, Hardt J, Monette J, Girre V, Springall E, Alibhai SMH. Use of geriatric assessment for older adults in the oncology setting: a systematic review. J Natl Cancer Inst. 2012;104:1133–63.
Lally F, Crome P. Understanding frailty. Postgrad Med J. 2007;83:16–20.
Rockwood K, Stadnyk K, MacKnight C, McDowell I, Hebert R, Hogan DB. A brief clinical instrument to classify frailty in elderly people. Lancet. 1999;353:205–6.
Tejedor P, Pastor C, Gonzalez-Ayora S, Ortega-Lopez M, Guadalajara H, Garcia-Olmo D. Short-term outcomes and benefits of ERAS program in elderly patients undergoing colorectal surgery: a case-matched study compared to conventional care. Int J Colorectal Dis. 2018;33:1251–8.
Lang P-O, Michel J-P, Zekry D. Frailty syndrome: a transitional state in a dynamic process. Gerontology. 2009;55:539–49.
Katz J, Weinrib A, Fashler SR, Katznelzon R, Shah BR, Ladak SS, et al. The Toronto General Hospital transitional pain service: development and implementation of a multidisciplinary program to prevent chronic postsurgical pain. J Pain Res. 2015;8:695–702.
Watkins LR, Maier SF, Goehler LE. Immune activation: the role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states. Pain. 1995;63:289–302.
Haddad JJ. On the enigma of pain and hyperalgesia: a molecular perspective. Biochem Biophys Res Commun. 2007;353:217–24.
De Jongh RF, Vissers KC, Meert TF, Booij LHDJ, De Deyne CS, Heylen RJ. The role of interleukin-6 in nociception and pain. Anesth Analg. 2003;96:1096–103.
Zhou Y-Q, Liu Z, Liu Z-H, Chen S-P, Li M, Shahveranov A, et al. Interleukin-6: an emerging regulator of pathological pain. J Neuroinflammation. 2016;13:141.
DeVon HA, Piano MR, Rosenfeld AG, Hoppensteadt DA. The association of pain with protein inflammatory biomarkers: a review of the literature. Nurs Res. 2014;63:51–62.
Kudoh A, Katagai H, Takazawa T. Antidepressant treatment for chronic depressed patients should not be discontinued prior to anesthesia. Can J Anesth. 2002;49:132–6.
Reikeras O, Borgen P, Reseland JE, Lyngstadaas SP. Changes in serum cytokines in response to musculoskeletal surgical trauma. BMC Res Notes. 2014;7:128.
Desborough JP. The stress response to trauma and surgery. Br J Anaesth. 2000;85:109–17.
Geiss A, Varadi E, Steinbach K, Bauer HW, Anton F. Psychoneuroimmunological correlates of persisting sciatic pain in patients who underwent discectomy. Neurosci Lett. 1997;237:65–8.
Oliver JB, Kashef K, Bader AM, Correll DJ. A survey of patients’ understanding and expectations of persistent postsurgical pain in a preoperative testing center. J Clin Anesth. 2016;34:494–501.
Tasmuth T, Smitten K, Hietanen P, Kataja M, Kalso E. Pain and other symptoms after different treatment modalities of breast cancer. Ann Oncol. 1995;6:453–9.
Poobalan AS, Bruce J, King PM, Chambers WA, Krukowski ZH, Smith WCS. Chronic pain and quality of life following open inguinal hernia repair. Br J Surg. 2001;88:1122–6.
Cornally N, McCarthy G. Chronic pain: the help-seeking behavior, attitudes, and beliefs of older adults living in the community. Pain Manag Nurs. 2011;12:206–17.
Falzone E, Hoffmann C, Keita H. Postoperative analgesia in elderly patients. Drugs Aging. 2013;30:81–90.
Turnheim K. When drug therapy gets old: pharmacokinetics and pharmacodynamics in the elderly. Exp Gerontol. 2003;38:843–53.
Denic A, Glassock RJ, Rule AD. Structural and functional changes with the aging kidney. Adv Chronic Kidney Dis. 2016;23:19–28.
Gibson SJ. Pain and aging: the pain experience over the adult lifespan. In: Dostrovsky JO, Carr DB, Koltzenburg M, editors. Proceedings of the 10th World Congress on Pain. Seattle: IASP; 2003. p. 767–790.
Garpestad E, Devlin JW. Polypharmacy and delirium in critically ill older adults: recognition and prevention. Clin Geriatr Med. 2017;33:189–203.
Hein C, Forgues A, Piau A, Sommet A, Nourhashémi F, Vellas B. Impact of polypharmacy on occurrence of delirium in elderly emergency patients. J Am Med Dir Assoc. 2014;15(850):e11–e15.
Field TS, Gurwitz JH, Avorn J, McCormick D, Jain S, Eckler M, et al. Risk factors for adverse drug events among nursing home residents. Arch Intern Med. 2001;161:1629–34.
Kaye AD, Baluch A, Scott JT. Pain management in the elderly population: a review. Ochsner J. 2010;10:179–87.
Weiner DK, Karp J, Berstein C, et al. Pain medicine in older adults: how should it differ? In: Deer T, Seong M, editors. Compr treat chronic pain by medical, Interv Behav approaches Am Acad Pain Med Textb patient Manag. New York: Springer; 2015. p. 233–258.
Berger M, Schenning KJ, Brown CH, Deiner SG, Whittington RA, Eckenhoff RG. Best practices for postoperative brain health: recommendations from the fifth international perioperative neurotoxicity working group. Anesth Analg. 2018;127:1406–13.
Jones J, Sim TF, Hughes J. Pain assessment of elderly patients with cognitive impairment in the emergency department: implications for pain management: a narrative review of current practices. Pharmacy (Basel). 2017;5:30.
Robinson S, Vollmer C. Undermedication for pain and precipitation of delirium. Medsurg Nurs. 2010;19:79–83.
Lynch EP, Lazor MA, Gellis JE, Orav J, Goldman L, Marcantonio ER. The impact of postoperative pain on the development of postoperative delirium. Anesth Analg. 1998;86:781–5.
Vaurio LE, Sands LP, Wang Y, Mullen EA, Leung JM. Postoperative delirium: the importance of pain and pain management. Anesth Analg. 2006;102:1267–73.
Swart LM, van der Zanden V, Spies PE, de Rooij SE, van Munster BC. The comparative risk of delirium with different opioids: a systematic review. Drugs Aging. 2017;34:437–43.
Latta KS, Ginsberg B, Barkin RL. Meperidine: a critical review. Am J Ther. 2002;9:53–68.
Subramaniam B, Shankar P, Shaefi S, Mueller A, O’Gara B, Banner-Goodspeed V, et al. Effect of intravenous acetaminophen vs placebo combined with propofol or dexmedetomidine on postoperative delirium among older patients following cardiac surgery: the DEXACET randomized clinical trial. JAMA. 2019;321:686–96.
Connolly KP, Kleinman RS, Stevenson KL, Neuman MD, Mehta SN. Delirium reduced with intravenous acetaminophen in geriatric hip fracture patients. J Am Acad Orthop Surg. 2020;28:325–31.
Politi JR, Davis RL, Matrka AK. Randomized prospective trial comparing the use of intravenous versus oral acetaminophen in total joint arthroplasty. J Arthroplasty. 2017;32:1125–7.
Whitlock EL, Diaz-Ramirez LG, Glymour MM, Boscardin WJ, Covinsky KE, Smith AK. Association between persistent pain and memory decline and dementia in a longitudinal cohort of elders. JAMA Intern Med. 2017;177:1146–53.
Marcantonio ER. Delirium in hospitalized older adults. N Engl J Med. 2018;378:96–7.
Fletcher D, Fermanian C, Mardaye A, Aegerter P. Pain and Regional Anesthesia Committee of the French Anesthesia and Intensive Care Society (SFAR). A patient-based national survey on postoperative pain management in France reveals significant achievements and persistent challenges. Pain. 2008;137:441–51.
Jin F, Chung F. Minimizing perioperative adverse events in the elderly. Br J Anaesth. 2001;87:608–24.
Fassoulaki A, Melemeni A, Stamatakis E, Petropoulos G, Sarantopoulos C. A combination of gabapentin and local anaesthetics attenuates acute and late pain after abdominal hysterectomy. Eur J Anaesthesiol. 2007;24:521–8.
Wilson JA, Nimmo AF, Fleetwood-Walker SM, Colvin LA. A randomised double blind trial of the effect of pre-emptive epidural ketamine on persistent pain after lower limb amputation. Pain. 2008;135:108–18.
Smith RV, Havens JR, Walsh SL. Gabapentin misuse, abuse and diversion: a systematic review. Addiction. 2016;111:1160–74.
Zhu W, Ding Z, Zhang Y, Shi J, Hashimoto K, Lu L. Risks associated with misuse of ketamine as a rapid-acting antidepressant. Neurosci Bull. 2016;32:557–64.
Şentürk M, Özcan PE, Talu GK, Kiyan E, Çamci E, Özyalçin S, et al. The effects of three different analgesia techniques on long-term postthoracotomy pain. Anesth Analg. 2002;94:11–5.
Tiippana E, Nilsson E, Kalso E. Post-thoracotomy pain after thoracic epidural analgesia: a prospective follow-up study. Acta Anaesthesiol Scand. 2003;47:433–8.
Brandsborg B, Nikolajsen L, Hansen CT, Kehlet H, Jensen TS. Risk factors for chronic pain after hysterectomy: a nationwide questionnaire and database study. Anesthesiology. 2007;106:1003–122.
Kalliomäki M-L, Meyerson J, Gunnarsson U, Gordh T, Sandblom G. Long-term pain after inguinal hernia repair in a population-based cohort; risk factors and interference with daily activities. Eur J Pain. 2008;12:214–25.
Katz J, Cohen L. Preventive analgesia is associated with reduced pain disability 3 weeks but not 6 months after major gynecologic surgery by laparotomy. Anesthesiology. 2004;101:169–74.
Wylde V, Dennis J, Beswick AD, Bruce J, Eccleston C, Howells N, et al. Systematic review of management of chronic pain after surgery. Br J Surg. 2017;104:1293–306.
Scott JC, Stanski DR. Decreased fentanyl and alfentanil dose requirements with age: a simultaneous pharmacokinetic and pharmacodynamic evaluation. J Pharmacol Exp Ther. 1987;240:159–66.
Dobscha SK, Corson K, Perrin NA, Hanson GC, Leibowitz RQ, Doak MN, et al. Collaborative care for chronic pain in primary care: a cluster randomized trial. JAMA. 2009;301:1242–52.
Notcutt W, Gibbs G. Inadequate pain management: myth, stigma and professional fear. Postgrad Med J. 2010;86:453–8.
Wang L, Chang Y, Kennedy SA, Hong PJ, Chow N, Couban RJ, et al. Perioperative psychotherapy for persistent post-surgical pain and physical impairment: a meta-analysis of randomised trials. Br J Anaesth. 2018;120:1304–14.
Jain SK, Dar MY, Kumar S, Yadav A, Kearns SR. Role of anti-oxidant (vitamin-C) in post-operative pain relief in foot and ankle trauma surgery: a prospective randomized trial. Foot Ankle Surg. 2019;25:542–5.
Reddi D. Preventing chronic postoperative pain. Anaesthesia. 2016;71:64–71.
De Oliveira GS, Almeida MD, Benzon HT, McCarthy RJ. Perioperative single dose systemic dexamethasone for postoperative pain: a meta-analysis of randomized controlled trials. Anesthesiology. 2011;115:575–88.
Rai A, Meng H, Weinrib A, Englesakis M, Kumbhare D, Grosman-Rimon L, et al. A review of adjunctive CNS medications used for the treatment of post-surgical pain. CNS Drugs. 2017;31:605–15.
McKeown JL. Pain management issues for the geriatric surgical patient. Anesthesiol Clin. 2015;33:563–76.
Nicholls JL, Azam MA, Burns LC, Englesakis M, Sutherland AM, Weinrib AZ, et al. Psychological treatments for the management of postsurgical pain: a systematic review of randomized controlled trials. Patient Relat Outcome Meas. 2018;9:49–644.
Jessen Lundorf L, Korvenius Nedergaard H, Møller AM. Perioperative dexmedetomidine for acute pain after abdominal surgery in adults. Cochrane Database Syst Rev. 2016;2:CD010358.
Daykin H. The efficacy and safety of intravenous lidocaine for analgesia in the older adult: a literature review. Br J Pain. 2017;11:23–31.
Sharrock NE. Epidural anesthetic dose responses in patients 20–80 years old. Anesthesiology. 1978;49:425–8.
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Gary Esses, Stacie Deiner, Fred Ko, and Yury Khelemsky have no conflicts of interest that are directly relevant to the content of this article.
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Fred Ko receives funding support from NIA K08 AG050808. Stacie Deiner receives funding support from NIA Beeson K23 and the American Federation of Aging Beeson Program.
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Esses, G., Deiner, S., Ko, F. et al. Chronic Post-Surgical Pain in the Frail Older Adult. Drugs Aging 37, 321–329 (2020). https://doi.org/10.1007/s40266-020-00761-2
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DOI: https://doi.org/10.1007/s40266-020-00761-2