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Quassilactones A and B, structural characterization of a new class of norquassinoids from Brucea javanica

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Abstract

Two novel norquassinoids possessing a unique ketal skeleton, designated quassilactones A (1) and B (2), were isolated from the fruits of Brucea javanica (Simaroubaceae). Their structures were established by extensive NMR and HR-ESI-MS spectroscopic analysis. The absolute configuration of 1 was determined through single-crystal X-ray crystallography, and that of 2 was assigned by comparing the calculated electronic and experimental circular dichroism with compound 1. In addition, their cytotoxic activities against three human cancer cell lines and their antimicrobial activities were evaluated.

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Acknowledgements

This work was jointly supported by funds from Guangxi Province Natural Science Foundation (2018GXNSFAA281146, 2018GXNSFAA281132, 2015GXNSFBA139026), the Special Fund of Bagui Scholars of Guangxi, the Scientific Research Fund of Guangxi University of Chinese Medicine (2017BS042, 2018ZD005-A08), National Natural Science Foundation of China (31760045, 81860655), the fund of Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences (AB2018009).

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Authors and Affiliations

  1. Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning, 530200, China

    Zhiwei Su, Kai Liu & Tingting Li

  2. National Demonstration Center for Experimental Plant Science Education, Agricultural College, Guangxi University, Nanning, 530004, China

    Zhonghui Ma

  3. Guangxi Key Laboratory of AIDS Prevention and Treatment and Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, School of Public Health, Guangxi Medical University, Nanning, 530021, China

    Bo Zhou

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  1. Zhiwei Su
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  2. Zhonghui Ma
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  4. Tingting Li
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Correspondence to Zhonghui Ma.

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Su, Z., Ma, Z., Liu, K. et al. Quassilactones A and B, structural characterization of a new class of norquassinoids from Brucea javanica. J Nat Med 74, 599–605 (2020). https://doi.org/10.1007/s11418-020-01407-8

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