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Inhibitory activities of phenylpropanoids from Lycopus lucidus on amyloid aggregation related to Alzheimer’s disease and type 2 diabetes

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Abstract

The number of patients with Alzheimer’s disease (AD) and type 2 diabetes (T2D) is increasing rapidly, and thus more research has been focused on the relationship between these two age-related chronic diseases. According to the amyloid hypothesis, prevention of the aggregation of amyloid β (Aβ) and human islet amyloid polypeptide (hIAPP) is a promising strategy for AD and T2D. In this study, thioflavin-T assay and transmission electron microscopy were performed to evaluate the inhibitory effect of three phenylpropanoids isolated from Lycopus lucidus—schizotenuin A and lycopic acids A and B—on both Aβ and hIAPP fibrillization. All tested compounds exhibited similarly strong inhibitory activity toward amyloid aggregation. These results suggested that catechol moieties play important roles in the inhibition of amyloid plaque formation.

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Acknowledgements

We thank Professor Kazuhiro Irie, Associate Professor Kazuma Murakami, and Dr Mizuho Hanaki, Graduate School of Agriculture, Kyoto University for preparing Aβ42. We would like to thank Editage (www.editage.com) for English language editing. This work was partially supported by JSPS KAKENHI Grant Number JP24580156.

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Authors and Affiliations

  1. Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8572, Japan

    Jiayi Sun

  2. Department of Pharmacognosy, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi, 981-8558, Japan

    Toshihiro Murata

  3. Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8572, Japan

    Hideyuki Shigemori

  4. Microbiology Research Center for Sustainability (MiCS), University of Tsukuba, Tsukuba, Ibaraki, 305-8572, Japan

    Hideyuki Shigemori

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  1. Jiayi Sun
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  2. Toshihiro Murata
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Correspondence to Hideyuki Shigemori.

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Sun, J., Murata, T. & Shigemori, H. Inhibitory activities of phenylpropanoids from Lycopus lucidus on amyloid aggregation related to Alzheimer’s disease and type 2 diabetes. J Nat Med 74, 579–583 (2020). https://doi.org/10.1007/s11418-020-01398-6

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  • DOI: https://doi.org/10.1007/s11418-020-01398-6

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