Cancer Cell
Volume 37, Issue 4, 13 April 2020, Pages 456-470
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Review
Advancing Cancer Research and Medicine with Single-Cell Genomics

https://doi.org/10.1016/j.ccell.2020.03.008Get rights and content
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Single-cell sequencing (SCS) has impacted many areas of cancer research and improved our understanding of intratumor heterogeneity, the tumor microenvironment, metastasis, and therapeutic resistance. The development and refinement of SCS technologies has led to massive reductions in costs, increased cell throughput, and improved reproducibility, paving the way for clinical applications. However, before translational applications can be realized, there are a number of logistical and technical challenges that must be overcome. This review discusses past cancer research studies, emerging technologies, and future clinical applications that are bound to transform cancer medicine.

Keywords

single cell genomics
translational genomics
cancer evolution
intratumor heterogeneity
single cell sequencing
metastasis
therapy resistance

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