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Association between chronic kidney disease and Alzheimer’s disease: an update

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Abstract

It has been accepted that kidney function is connected with brain activity. In clinical studies, chronic kidney disease (CKD) patients have been found to be prone to suffering cognitive decline and Alzheimer’s disease (AD). The cognitive function of CKD patients may improve after kidney transplantation. All these indicators show a possible link between kidney function and dementia. However, little is known about the mechanism behind the relation of CKD and AD. This review discusses the associations between CKD and AD from the perspective of the pathophysiology of the kidney and complications and/or concomitants of CKD that may lead to cognitive decline in the progression of CKD and AD. Potential preventive and therapeutic strategies for AD are also presented. Further studies are warranted in order to confirm whether the setting of CKD is a possible new determinant for cognitive impairment in AD.

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Acknowledgements

This work was supported by grants from the National Natural Science Foundation of China (No. 81974162, No. 81670166, and No. 81770711) and the National Key R&D Program of China (2018YFC1314000).

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  1. Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Chun-Yun Zhang, Fang-Fang He, Hua Su & Chun Zhang

  2. Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Xian-Fang Meng

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Zhang, CY., He, FF., Su, H. et al. Association between chronic kidney disease and Alzheimer’s disease: an update. Metab Brain Dis 35, 883–894 (2020). https://doi.org/10.1007/s11011-020-00561-y

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  • DOI: https://doi.org/10.1007/s11011-020-00561-y

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