Abstract
Hericerin is an isoindolinone meroterpenoid alkaloid isolated from medicinal mushroom Hericium erinaceum with some bioactivities. Herein, a concise total synthesis of hericerin was described, with four steps and 30% overall yield starting from commercially available methyl 3-hydroxy-5-methoxybenzoate and geranyl bromide. A comprehensive effect of hericerin on HepG2 cell line was observed and confirmed by transcriptomic analysis. Furthermore, hericerin was found to be a new PPARĪ³ agonist.
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Acknowledgements
This study was supported by the National Natural Science Foundation of China (21472233 and 21877124).
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Zheng, Z., Chen, B., Wang, K. et al. A concise total synthesis and PPAR activation activity of hericerin from Hericium erinaceum. J Antibiot 73, 646ā649 (2020). https://doi.org/10.1038/s41429-020-0303-8
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DOI: https://doi.org/10.1038/s41429-020-0303-8