Targeting TGFβ Signalling in Cancer: Toward Context-Specific Strategies

doi:10.1016/j.trecan.2020.03.010

Trends in Cancer

Volume 6, Issue 7, July 2020, Pages 538-540

https://doi.org/10.1016/j.trecan.2020.03.010 Get rights and content

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The transforming growth factor beta (TGFβ) signalling pathway regulates a range of important cellular processes in a context-dependent manner. Recent discoveries have provided important insights into the regulation of the TGFβ pathway and its change from an antitumorigenic to a protumorigenic pathway. These findings may have important implications for cancer stem cell (CSC) functions and therapeutic strategies.

Keywords

TGFβ signalling pathway

Smad2/3

gene expression

epithelial-to-mesenchymal transition

pancreatic tumorigenesis

cancer stem cells

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²: These authors contributed equally to this work.

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Targeting TGFβ Signalling in Cancer: Toward Context-Specific Strategies