Issue 10, 2020
From the journal:

Organic Chemistry Frontiers

Total synthesis of tumor-associated KH-1 antigen core nonasaccharide via photo-induced glycosylation†

Bo-Han Li,‡a   Wenlong Yao,‡b   Hong Yang,‡bc   Congying Wu,a   De-Cai Xiong,*bd   Yuxin Yin*a  and  Xin-Shan Ye ORCID logo *b  

* Corresponding authors

a Institute of Systems Biomedicine, Department of Pathology, Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China
E-mail: yinyuxin@hsc.pku.edu.cn

b State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road No. 38, Beijing 100191, China
E-mail: xinshan@bjmu.edu.cn, decai@bjmu.edu.cn

c National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang 330022, China

d Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, 27 Shanda Nanlu, Jinan, Shandong 250100, China

Abstract

The synthesis of tumor-associated KH-1 antigen core nonasaccharide was achieved. All key glycosidic linkages were efficiently constructed by photo-induced glycosylation. The success of this total synthesis provides an example for the preparation of complex oligosaccharides using light-driven glycosylation reactions.

Graphical abstract: Total synthesis of tumor-associated KH-1 antigen core nonasaccharide via photo-induced glycosylation

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Article information

DOI
https://doi.org/10.1039/D0QO00314J
Article type
Research Article
Submitted
10 Mar 2020
Accepted
02 Apr 2020
First published
03 Apr 2020

Org. Chem. Front., 2020,7, 1255-1259

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Total synthesis of tumor-associated KH-1 antigen core nonasaccharide via photo-induced glycosylation

B. Li, W. Yao, H. Yang, C. Wu, D. Xiong, Y. Yin and X. Ye, Org. Chem. Front., 2020, 7, 1255 DOI: 10.1039/D0QO00314J

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