Sustainable chemo-enzymatic preparation of enantiopure (R)-β-hydroxy-1,2,3-triazoles via lactic acid bacteria-mediated bioreduction of aromatic ketones and a heterogeneous “click” cycloaddition reaction in deep eutectic solvents†
Paola
Vitale, 
*a
Francesca
Valerio,
*b
Mariaelena
Di Biase,
b
Filippo Maria
Perna,
a
Eugenia
Messina,
cd
Gennaro
Agrimi,
cd
Isabella
Pisano
cd
and
Vito
Capriati
*ae
*a
Francesca
Valerio,
*b
Mariaelena
Di Biase,
b
Filippo Maria
Perna,
a
Eugenia
Messina,
cd
Gennaro
Agrimi,
cd
Isabella
Pisano
cd
and
Vito
Capriati
*ae
Abstract
Enantiomerically pure (R)-β-hydroxy-1,2,3-triazole derivatives, which are important β-blocker analogues, have been synthesized by exploiting an unusual Prelog enantioselective reduction of aromatic azido ketones by whole cells of a lactic acid bacterium (Weissella cibaria C43-11) and a “click” cycloaddition reaction carried out in deep eutectic solvents, under heterogeneous and aerobic conditions at room temperature.
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