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Vasopressin in Relation to Selected Oxidative Stress Markers as Etiological Mechanism of Autism

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Abstract

The marked heterogeneity of autism spectrum disorders is a challenge for research into biomarkers of these disorders. The present study aimed to assess the association of the thioredoxin (TRX) system and vasopressin with autism in children. Thirty-five autistic children were recruited with thirty-one healthy controls children matched for age and gender. Total antioxidant capacity (TAC), vasopressin, peroxiredoxin (PRDX1, PRDX3), phox domain-containing protein kinase-like protein, and TRX1 levels were measured in plasma and mercury and lead levels were measured in red blood cells. Children with autism had significantly lower levels of PRDX1 and TRX1 and significantly higher levels of lead and mercury compared with controls. Significantly higher levels of vasopressin were also observed in more severe cases of autism. Receiver operating characteristics analysis demonstrated satisfactory specificity and sensitivity of TAC, PRDX1, PRDX3, and TRX1 for the diagnosis of autism. The optimal cut-off value for plasma TRX1 levels, as an indicator of autism, was 10.6 ng/mL. Significant positive correlations existed between TRX system components, lead, and mercury. A negative correlation was found between vasopressin and TRX1, but positive correlations were found between vasopressin and mercury and lead. In conclusion, TAC, PRDX1, PRDX3, and TRX1 may be useful biomarkers for the diagnosis of autism in Saudi populations. Vasopressin-resistance in autistic patients may be due to an increased oxidative burden.

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Funding

This work was funded by the National Plan for Science Technology and Innovation (MAARIFAH), King Abdulaziz City for Science and Technology, Kingdom of Saudi Arabia, Award number: 08-MED 510-02.

Author information

Authors and Affiliations

  1. Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia

    W. A. Al-Zahrani & R. S. Bhat

  2. Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia

    L. Al-Ayadhi

  3. Autism Research and Treatment Center, Riyadh, Saudi Arabia

    L. Al-Ayadhi

  4. Department of Research on Children with Special Needs, National Research Centre, Giza, Egypt

    M. Anwar

  5. Department of Basic Science and Biomechanics, College of Physical Therapy, Heliopolis University, Cairo, Egypt

    M. Anwar

  6. Central Laboratory, Female Centre for Scientific and Medical Studies, King Saud University, PO BOX 22452, 11495, Riyadh, Saudi Arabia

    O. Alnakhli & A. El-Ansary

  7. Prince Naif for Health Research Center, King Saud University, Riyadh, Saudi Arabia

    O. Alnakhli

  8. Therapeutic Chemistry Department, National Research Center, Giza, Egypt

    N. Zayed & A. El-Ansary

  9. Council for Nutritional and Environmental Medicine (CONEM) Norway and Head of CONEM Saudi Child Brain Research Group, Riyadh, Saudi Arabia

    A. El-Ansary

Authors
  1. W. A. Al-Zahrani
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  2. L. Al-Ayadhi
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  4. R. S. Bhat
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  7. A. El-Ansary
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Correspondence to A. El-Ansary.

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Conflict of interest. The authors declare no potential conflict of interest with respect to the authorship, and /or publication of this article.

Ethical approval. All procedures performed in the current study was approved by the Ethical committee of the college of Medicine, King Saud University in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments ethical standards.

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Al-Zahrani, W.A., Al-Ayadhi, L., Anwar, M. et al. Vasopressin in Relation to Selected Oxidative Stress Markers as Etiological Mechanism of Autism. Neurochem. J. 14, 116–125 (2020). https://doi.org/10.1134/S181971242001002X

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  • DOI: https://doi.org/10.1134/S181971242001002X

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