Issue 16, 2020
From the journal:

Organic & Biomolecular Chemistry

Regioselective hydroarylation and arylation of maleimides with indazoles via a Rh(iii)-catalyzed C–H activation†

Asim Kumar Ghosh,a   Sadhanendu Samanta, ORCID logo a   Payel Ghosh,a   Sukanya Neogia  and  Alakananda Hajra ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Visva-Bharati (A Central University) Santiniketan, West Bengal, India
E-mail: alakananda.hajra@visva-bharati.ac.in
Web: http://vbchem.ac.in/AlakanandaHajra/

Abstract

Switchable Rh(III)-catalyzed highly regioselective hydroarylation and oxidative arylation of maleimides with 2-arylindazoles via C–H activation have been demonstrated. The reaction affords 3-(2-(2H-indazol-2-yl)phenyl)succinimide and 3-(2-(2H-indazol-2-yl)phenyl)maleimide derivatives in high yields with wide functional group tolerance. A mechanistic study was performed to depict C–H bond cleavage that might be involved in the turnover limiting step.

Graphical abstract: Regioselective hydroarylation and arylation of maleimides with indazoles via a Rh(iii)-catalyzed C–H activation

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Article information

DOI
https://doi.org/10.1039/D0OB00353K
Article type
Paper
Submitted
17 Feb 2020
Accepted
28 Mar 2020
First published
30 Mar 2020

Org. Biomol. Chem., 2020,18, 3093-3097

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Regioselective hydroarylation and arylation of maleimides with indazoles via a Rh(III)-catalyzed C–H activation

A. K. Ghosh, S. Samanta, P. Ghosh, S. Neogi and A. Hajra, Org. Biomol. Chem., 2020, 18, 3093 DOI: 10.1039/D0OB00353K

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