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Effective nanotherapeutic approach for metastatic breast cancer treatment by supplemental oxygenation and imaging-guided phototherapy

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Abstract

Metastasis remains the primary cause for mortality of breast cancer. Despite advances in current therapeutic agents, patients with metastatic breast cancer still have poor prognoses. Tumor hypoxia, a key microenvironment factor, is emerging as an attractive target to prevent metastasis and is also involved with resistance to phototherapy. Here, we show an effective nanotherapeutic approach based on manganese dioxide-coated polydopamine nanocarriers to trigger robust anti-tumor and anti-metastasis responses against metastatic breast cancer by supplemental oxygenation and multimodal imaging-guided phototherapies. In cancer cells, the produced oxygen by the developed nanoplatform decreases the expression of hypoxia-inducible factors 1\ga to inhibit tumor metastasis, and enhances the efficacy of photodynamic therapy. This nanotherapeutic approach enables the combined photodynamic/photothermal treatments with great inhibition on cell migration and invasion in vitro. Moreover, the nanotherapeutics effectively suppresses primary tumor progress and inhibits lung metastasis in vivo in a breast cancer mouse model with satisfying biosafety. This study suggests that the tumor hypoxia-targeting nanotherapeutics have great potential for preventing and treating metastatic cancers.

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Acknowledgements

This work is supported by the National Natural Science Foundation of China (Nos. 81602610 and 21874103), and Fundamental Research Funds for the Central Universities (Nos. 2042018kf1006 and 2042018kf0210).

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  1. Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China

    Jialing Hu, Fuan Wang, Feng Liu, Wentong Sun, Qunying Jiang, Yahua Liu, Yun Zhao & Xiaoqing Liu

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  1. Jialing Hu
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  2. Fuan Wang
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  3. Feng Liu
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  5. Qunying Jiang
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  8. Xiaoqing Liu
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Correspondence to Xiaoqing Liu.

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Effective nanotherapeutic approach for metastatic breast cancer treatment by supplemental oxygenation and imaging-guided phototherapy

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Hu, J., Wang, F., Liu, F. et al. Effective nanotherapeutic approach for metastatic breast cancer treatment by supplemental oxygenation and imaging-guided phototherapy. Nano Res. 13, 1111–1121 (2020). https://doi.org/10.1007/s12274-020-2753-5

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