Synthesis 2020; 52(12): 1847-1854
DOI: 10.1055/s-0040-1708006
paper
© Georg Thieme Verlag Stuttgart · New York

Facile Construction of Troponoid Derivatives Incorporating Imidazolin-2-one Moieties

Jing Yu
a   Jiangsu Key Laboratory of Neuropsychiatric Diseases & College of Pharmaceutical Sciences, Soochow University, 199 Ren’ai Road, Suzhou, Jiangsu, 215123, P. R. of China   Email: huyanwei@suda.edu.cn   Email: zhangshilei@suda.edu.cn
,
Xiaobei Chen
b   State Key Laboratory of Bioengineering Reactor, and Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, P. R. of China
,
Ye Liu
a   Jiangsu Key Laboratory of Neuropsychiatric Diseases & College of Pharmaceutical Sciences, Soochow University, 199 Ren’ai Road, Suzhou, Jiangsu, 215123, P. R. of China   Email: huyanwei@suda.edu.cn   Email: zhangshilei@suda.edu.cn
,
Bing Wu
d   College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren’ai Road, Suzhou, Jiangsu, 215123, P. R. of China
,
Haiyan Li
d   College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren’ai Road, Suzhou, Jiangsu, 215123, P. R. of China
,
Yanwei Hu
a   Jiangsu Key Laboratory of Neuropsychiatric Diseases & College of Pharmaceutical Sciences, Soochow University, 199 Ren’ai Road, Suzhou, Jiangsu, 215123, P. R. of China   Email: huyanwei@suda.edu.cn   Email: zhangshilei@suda.edu.cn
,
Liang Wang
c   College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, P. R. of China   Email: liangwang0532@yeah.net
,
Shilei Zhang
a   Jiangsu Key Laboratory of Neuropsychiatric Diseases & College of Pharmaceutical Sciences, Soochow University, 199 Ren’ai Road, Suzhou, Jiangsu, 215123, P. R. of China   Email: huyanwei@suda.edu.cn   Email: zhangshilei@suda.edu.cn
› Author Affiliations
The project was supported by National Natural Science Foundation of China (21202112, 21702058, 21738002 and 21776148), PAPD (A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions). We are also grateful for the financial support from the Natural Science Foundation of Shandong Province (ZR2016BM07) and the Qingdao Special Research Foundation of Science and Technology (16-6-2-29-nsh).
Further Information

Publication History

Received: 19 January 2020

Accepted after revision: 02 March 2020

Publication Date:
26 March 2020 (online)


Abstract

Troponoid derivatives incorporating imidazolin-2-one moieties were efficiently constructed via a cascade process, under simple thermal conditions, which features a novel nitrogen source, is catalyst- and oxidant-free, and has high atom- and step-economy.

Supporting Information

 
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