Original ArticleHyperthermia affects collagen fiber architecture and induces apoptosis in pancreatic and fibroblast tumor hetero-spheroids in vitro
Graphical Abstract
Mild hyperthermia affects the fibrillary collagen architecture of pancreatic hetero-type tumor spheroids and induces cell death via apoptosis and necrosis.
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Disclosure: Ingrid Hilger declares that she is holding a patent DE 10 2005 062 746. Conflict of interest statement/financial support information: The authors report no conflict of interest in this work.
Acknowledgements
This work was funded by the European Commission (NoCanTher, EC685795), in part by the Federal Ministry of Education and Research (BMBF, grant number 03XP0003) and by the Interdisciplinary Center of Clinical Research (IZKF) of the University Hospital Jena. We thank Julia Göring and Susann Burgold for their excellent technical support and the Jena Biophotonics and Imaging Laboratory (JBIL) for providing the multiphoton microscope. We are thankful to Dr. Katja Grün (University Hospital Jena) for her support in performing histochemistry.
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These authors contributed equally.