Issue 35, 2020

Copper-catalyzed tandem cis-carbometallation/cyclization of imine-ynamides with arylboronic acids

Abstract

An efficient copper-catalyzed tandem regioselective cis-carbometallation/cyclization of imine-ynamides with arylboronic acids has been developed. This method leads to a facile and practical synthesis of valuable 2,3-disubstituted indolines in moderate to excellent yields and features a broad substrate scope and wide functional group tolerance. Other significant features of this protocol include the use of readily available starting materials, high flexibility, simple procedure and mild reaction conditions.

Graphical abstract: Copper-catalyzed tandem cis-carbometallation/cyclization of imine-ynamides with arylboronic acids

Supplementary files

Article information

Article type
Communication
Submitted
24 Feb 2020
Accepted
23 Mar 2020
First published
24 Mar 2020

Chem. Commun., 2020,56, 4832-4835

Copper-catalyzed tandem cis-carbometallation/cyclization of imine-ynamides with arylboronic acids

H. Wang, E. Huang, C. Luo, W. Luo, Y. Xu, P. Qian, J. Zhou and L. Ye, Chem. Commun., 2020, 56, 4832 DOI: 10.1039/D0CC01424A

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