Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Congenital cytomegalovirus infection and audiological follow-up: electrophysiological auditory threshold before 3 months of age as a predictor of hearing outcome at 3 years of age

Journal of Perinatology volume 40, pages 1216–1221 (2020)Cite this article

Subjects

Abstract

Objective

We aimed to evaluate whether electrophysiological auditory thresholds (EATs) before 3 month of age, as assessed by the auditory brainstem responses (ABR) test and the auditory steady state responses (ASSR) test, can predict hearing outcome at 3 years of age among children born with congenital cytomegalovirus (cCMV) infection.

Study design

Audiological assessment was performed before 3 months of age, and every 6 months thereafter until 3 years of age, in a population of 63 children (126 ears). EATs before 3 months of age and at 3 years of age were compared.

Result

No ear with an EAT of ≤30 dBHL (i.e. normal hearing) before 3 months of age showed worsening EATs at 3 years of age.

Conclusion

An EAT of ≤30 dBHL obtained by ABR and ASSR tests before 3 months of age is predictive of a normal hearing at 3 years of age in children born with cCMV.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Results of the auditory brainstem responses (ABR) test at the first and sixth audiological assessment.
Fig. 2: Results of the auditory steady state responses (ASSR) test 500–4000 Hz at the first and sixth audiological assessment.

Similar content being viewed by others

References

  1. Kenneson A, Cannon MJ. Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection. Rev Med Virol. 2007;17:253–76.

    Article  Google Scholar 

  2. Gaytant MA, Steegers EAP, Semmekrot BA, Merkus HMMW, Galama JMD. Congenital cytomegalovirus infection: review of the epidemiology and outcome. Obstet Gynecol Surv. 2002;57:245–56.

    Article  Google Scholar 

  3. Bodéus M, Kabamba-Mukadi B, Zech F, Hubinont C, Bernard P, Goubau P. Human cytomegalovirus in utero transmission: follow-up of 524 maternal seroconversions. J Clin Virol. 2010;47:201–2.

    Article  Google Scholar 

  4. Kylat R, Kelly E, Ford-Jones E. Clinical findings and adverse outcome in neonates with symptomatic congenital cytomegalovirus (SCCMV) infection. Eur J Pediatr. 2006;165:773–8.

    Article  Google Scholar 

  5. Goderis J, De Leenheer E, Smets K, Van Hoecke H, Keymeulen A, Dhooge I. Hearing loss and congenital cmv infection: a systematic review. Pediatrics. 2014;134:972–82.

    Article  Google Scholar 

  6. Grosse SD, Ross DS, Dollard SC. Congenital cytomegalovirus (CMV) infection as a cause of permanent bilateral hearing loss: a quantitative assessment. J Clin Virol. 2008;41:57–62.

    Article  Google Scholar 

  7. Fowler KB, Dahle AJ, Boppana SB, Pass RF. Newborn hearing screening: will children with hearing loss due to congenital cytomegalovirus infection be missed? J Pediatr. 1999;135:60–4.

    Article  CAS  Google Scholar 

  8. Fowler KB. Congenital cytomegalovirus infection: audiologic outcome. Clin Infect Dis. 2013;57 Suppl 4:S182–4.

    Article  Google Scholar 

  9. Berrettini S, Ghirri P, Lazzerini F, Lenzi G, Forli F. Newborn hearing screening protocol in tuscany region. Ital J Pediatrics. 2017;43:82.

    Article  Google Scholar 

  10. Rawlinson WD, Boppana SB, Fowler KB, Kimberlin DW, Lazzarotto T, Alain S, et al. Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy. Lancet Infect Dis. 2017;S1473-3099:30143–3.

    Google Scholar 

  11. Joint Committee on Infant Hearing Year 2007 position statement: principles and guidelines for early hearing detection and intervention programs. Pediatrics. 2007;120:898–921.

    Article  Google Scholar 

  12. Royackers L, Rector E, Verhaert N, Desloovere C. Long-term audiological follow-up of children with congenital cytomegalovirus. B-ENT. 2013;9 Suppl 21:57–64.

    Google Scholar 

  13. Lins OG, Picton TW. Auditory steady-state responses to multiple simultaneous stimuli. Electroencephalogr Clin Neurophysiol. 1995;96:420–32.

    Article  CAS  Google Scholar 

  14. Joint Committee on Infant Hearing 1994 Position Statement. American Academy of Pediatrics Joint Committee on Infant Hearing. Pediatrics. 1995;95:152–6.

    Google Scholar 

  15. Bertino E, Spada E, Occhi L, Coscia A, Giuliani F, Gagliardi L, et al. Neonatal anthropometric charts: the Italian neonatal study compared with other European studies. JPGN. 2010;51:353–61.

    PubMed  Google Scholar 

  16. Naing ZW, Scott GM, Shand A, Hamilton ST, van Zuylen WJ, Basha J, et al. Congenital cytomegalovirus infection in pregnancy: a review of prevalence, clinical features, diagnosis and prevention. Aust NZ J Obstet Gynaecol. 2016;56:9–18.

    Article  Google Scholar 

  17. Silva DPC, Lopez PS, Montovani JC. Auditory steady state response in hearing assessment in infants with cytomegalovirus. Rev Paul Pediatr. 2013;31:550–3.

    Article  Google Scholar 

  18. Johnson TA, Brown CJ. Threshold prediction using the auditory steady-state response and the tone burst auditory brain stem response: a within subject comparison. Ear Hear. 2005;26:559–76.

    Article  Google Scholar 

  19. Ribeiro FM, Carvallo RM, Marcoux AM. Auditory steady-state evoked responses for preterm and term neonates. Audio Neurootol. 2010;15:97–110.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Neonatal Unit of the University, City of Health and Science Hospital of Turin, Turin, Italy

    A. Coscia, M. Sorrenti, A. Leone, G. Marengo, C. Peila, E. Bertino & F. Cresi

  2. Audiology and Cochlear Implants Service, Simple Departmental Structure of Otolaryngology, Martini Hospital of Turin, Turin, Italy

    D. Di Lisi, P. Consolino & M. G. Vergnano

  3. Department of Public Health and Pediatrics, University of Turin, Turin, Italy

    E. Spada

Authors
  1. A. Coscia
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Sorrenti
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Leone
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D. Di Lisi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. P. Consolino
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M. G. Vergnano
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. G. Marengo
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. E. Spada
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. C. Peila
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. E. Bertino
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. F. Cresi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. Sorrenti.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethics approval

Ethics approval was provided by the ethical committee of the City of Health and Science Hospital of Turin (Italy), Protocol number 0041678.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Coscia, A., Sorrenti, M., Leone, A. et al. Congenital cytomegalovirus infection and audiological follow-up: electrophysiological auditory threshold before 3 months of age as a predictor of hearing outcome at 3 years of age. J Perinatol 40, 1216–1221 (2020). https://doi.org/10.1038/s41372-020-0655-8

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41372-020-0655-8

Search

Advanced search

Quick links