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Luseogliflozin, a sodium-glucose cotransporter 2 inhibitor, preserves renal function irrespective of acute changes in the estimated glomerular filtration rate in Japanese patients with type 2 diabetes

Hypertension Research volume 43, pages 876–883 (2020)Cite this article

Abstract

Acute decline in estimated glomerular filtration rate (eGFR), a typical finding after initiating sodium-glucose cotransporter 2 (SGLT2) inhibitors, is associated with maintaining renal function in type 2 diabetes. However, the relationship between the magnitude of acute decline in eGFR and the course of eGFR thereafter is not known. A pooled analysis of four 52-week phase III trials of luseogliflozin 2.5 mg daily (or up to 5 mg daily) in Japanese patients with type 2 diabetes was conducted and stratified according to the tertile of magnitude of acute change in eGFR during the 2 weeks after initiation. The mean age, glycated hemoglobin, eGFR, and urinary albumin were 60 years, 7.8%, 79.6 mL/min/1.73 m2, and 62.7 mg/g Cr, respectively. Acute change in eGFR varied widely between patients (N = 941; mean, −2.3; min, −35.5; max, 27.6). Patients with greater acute decline in eGFR, characterized by higher baseline eGFR and increased diuretic use, showed rapid recovery and maintenance of eGFR thereafter. Higher eGFR, longer duration of diabetes, and higher body mass index and diuretic use were associated with greater acute decline in eGFR. The course of eGFR from 12 to 52 weeks was maintained regardless of acute changes. Although acute changes in eGFR varied widely among patients with type 2 diabetes, the course of eGFR thereafter was stable regardless of the degree of acute changes.

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Acknowledgements

This study was funded by Taisho Pharmaceutical Co., Ltd. Statistical analysis of this study was conducted at Taisho Pharmaceutical Co., Ltd. Editorial assistance for the preparation of this paper was provided by Cactus Communications and funded by Taisho Pharmaceutical Co., Ltd. We thank Dr Haneda, Dr Inagaki, Dr Kaku, Dr Sasaki, Dr Fukatsu, and all other physicians who participated in the phase III trial of luseogliflozin.

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Authors and Affiliations

  1. Dialysis Unit, University of the Ryukyus Hospital, Okinawa, Japan

    Kentaro Kohagura

  2. Department of Cardiovascular Medicine, Nephrology and Neurology Faculty of Medicine, University of the Ryukyus, Okinawa, Japan

    Kentaro Kohagura & Yusuke Ohya

  3. Taisho Pharmaceutical Co., Ltd., Tokyo, Japan

    Hironori Yamasaki & Hiroki Takano

  4. Kansai Electric Power Hospital, Osaka, Japan

    Yutaka Seino

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  1. Kentaro Kohagura
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Contributions

KK wrote the paper and researched the data. YO contributed to the discussion. YS reviewed the paper. HY and HT researched the data and contributed to the discussion.

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Correspondence to Kentaro Kohagura.

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Conflict of interest

KK has received speaker’s fees from Nippon Boehringer Ingelheim Co., Ltd, Mitsubishi Tanabe Pharma Co., Ltd, Astellas Pharma Inc., MSD K.K., Ono Pharmaceutical Co., Ltd, AstraZeneca K.K., and Taisho Toyama Pharmaceutical Co., Ltd. YO has received speaker’s fees from Nippon Boehringer Ingelheim Co., Ltd, Takeda Pharmaceutical Co., Ltd, Daiichi Sankyo Pharmaceutical Co., Ltd. YS has received consulting and/or speaker’s fees from MSD K.K., Kao Co., Ltd, Novo Nordisk Pharma Inc., Taisho Pharmaceutical Co., Ltd, Taisho Toyama Pharmaceutical Co., Ltd, Nippon Becton, Dickinson and Company, Nippon Boehringer Ingelheim Co., Ltd, and Takeda Pharmaceutical Co., Ltd. HY and HT are employees of Taisho Pharmaceutical Co., Ltd.

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Kohagura, K., Yamasaki, H., Takano, H. et al. Luseogliflozin, a sodium-glucose cotransporter 2 inhibitor, preserves renal function irrespective of acute changes in the estimated glomerular filtration rate in Japanese patients with type 2 diabetes. Hypertens Res 43, 876–883 (2020). https://doi.org/10.1038/s41440-020-0426-0

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