Skip to main content
SpringerLink
Log in

Histone Tails Promote PARP1-Dependent Structural Rearrangements in Nucleosomes

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
  • Published:
Doklady Biochemistry and Biophysics Aims and scope Submit manuscript

Abstract

PARP 1 alters the wrapping of nucleosomal DNA on the histone octamer, thereby modulating the accessibility of different genome sites to nuclear protein factors. Here, we show that non-structured histone tails are involved in the PARP1-induced structural rearrangements in nucleosomes, facilitate and stabilize them, but do not affect the enzymatic activity of PARP1.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.

Similar content being viewed by others

REFERENCES

  1. Wang Y., Luo, W., and Wang, Y., DNA Repair (Amsterdam), 2019, vol. 8, p. 102651.

    Article  Google Scholar 

  2. Posavec Marjanović, M., Crawford, K., and Ahel, I., Semin. Cell Dev. Biol., 2017, vol. 63, pp. 102–113.

    Article  Google Scholar 

  3. Thomas, C., Ji, Y., Wu, C., Datz, H., Boyle, C., MacLeod, B., Patel, S., Ampofo, M., Currie, M., Harbin, J., Pechenkina, K., Lodhi, N., Johnson, S.J., and Tulin, A.V., Proc. Natl. Acad. Sci. U. S. A., 2019, vol. 116, pp. 9941–9946.

    Article  CAS  Google Scholar 

  4. Krishnakumar, R., Gamble, M., Frizzell, K.M., Berrocal, J.G., Kininis, M., and Kraus, W.L., Science, 2008, vol. 319, pp. 819–821.

    Article  CAS  Google Scholar 

  5. Liu, Z. and Kraus, K., Mol. Cell, 2017, vol. 65, pp. 589–603.

    Article  CAS  Google Scholar 

  6. Sultanov, D.C., Gerasimova, N.S., Kudrjashova, K., Maluchenko, N.V., Kotova, E.Y., Langelier, M.F., Pascal, J.M., Kirpichnikov, M.P., Feofanov, A.V., and Studitsky, V.M., AIMS Genet., 2017, vol. 4, pp. 21–31.

    Article  Google Scholar 

  7. Azad, G.K., Swagatika, K.M., Kumawat, R., and Tomar, R.S., J. Mol. Biol., 2018, vol. 430, pp. 3051–3067.

    Article  CAS  Google Scholar 

  8. Gaykalova, D.A., Kulaeva, O.I., Bondarenko, V.A., and Studitsky, V.M., Methods Mol. Biol., 2009, vol. 523, pp. 109–123.

    Article  CAS  Google Scholar 

  9. Luger, K., Rechsteiner, T., Flaus, A.J., Waye, M.M., and Richmond, T.J., J. Mol. Biol., 1997, vol. 27, pp. 301–311.

    Article  Google Scholar 

  10. Langelier, M.F., Planck, J.L., Servent, K.M., and Pascal, J.M., Methods Mol. Biol., 2011, vol. 780, pp. 209–226.

    Article  CAS  Google Scholar 

  11. Clark, N.J., Kramer, M., Muthurajan, U.M., and Luger, K., J. Biol. Chem., 2012, vol. 287, pp. 32430–32439.

    Article  CAS  Google Scholar 

  12. Kudryashova, K.S., Nikitin, D.V., Chertkov, O.V., Gerasimova, N.S., Valeva, M.E., Studitsky, V.M., and Feofanov, A.V., Moscow Univ. Biol. Sci. Bull., 2015, vol. 70, pp. 189–193.

    Article  Google Scholar 

Download references

Funding

The study was supported by the Russian Foundation for Basic Research (project no. 17-54-33045).

Author information

Authors and Affiliations

  1. Moscow State University, 119234, Moscow, Russia

    N. V. Maluchenko,  M. P. Kirpichnikov, V. M. Studitsky & A. V. Feofanov

  2. Fox Chase Cancer Center, Philadelphia, USA

    D. S. Sultanov, E. Yu. Kotova & V. M. Studitsky

  3. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia

    M. P. Kirpichnikov & A. V. Feofanov

Authors
  1. N. V. Maluchenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. S. Sultanov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. Yu. Kotova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. P. Kirpichnikov
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. V. M. Studitsky
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. V. Feofanov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N. V. Maluchenko.

Ethics declarations

The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.

Additional information

Translated by M. Batrukova

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Maluchenko, N.V., Sultanov, D.S., Kotova, E.Y. et al. Histone Tails Promote PARP1-Dependent Structural Rearrangements in Nucleosomes. Dokl Biochem Biophys 489, 377–379 (2019). https://doi.org/10.1134/S1607672919060061

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1607672919060061

Search

Navigation