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Update on naturally occurring novel arylnaphthalenes from plants

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Abstract

Arylnaphthalene compounds, also called cyclolignolides, are lignans and have been extensively studied and documented, especially podophyllotoxin and its derivatives. Great progress has been made in phytochemical studies on arylnaphthalenes in the last 20 years (1999–2019), and arylnaphthalenes have been reported to have various biological activities. A total of 338 new arylnaphthalene compounds from over 60 families, including Acanthaceae, Phyllanthaceae, Lamiaceae, Lauraceae, Schisandraceae, Berberidaceae, and Boraginaceae, have been discovered. This paper will highlight their structural features, sources, and biological activities and briefly discuss their structure–activity relationships.

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Acknowledgements

We thank the authors of all the references cited herein for their valuable contributions. This project was financially supported by the Natural Science Foundation of China (Grants 81173505).

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  1. Gene Engineering and Biotechnology Beijing Key Laboratory, College of Life Science, Beijing Normal University, 19 XinjiekouWai Avenue, Beijing, 100875, People’s Republic of China

    Shoujie Li, Zizhen Liang, Jinjie Li, Xuan Zhang, Ruihong Zheng & Changqi Zhao

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  1. Shoujie Li
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  2. Zizhen Liang
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Correspondence to Changqi Zhao.

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Li, S., Liang, Z., Li, J. et al. Update on naturally occurring novel arylnaphthalenes from plants. Phytochem Rev 19, 337–403 (2020). https://doi.org/10.1007/s11101-020-09668-7

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