Molecular Cell

Molecular Cell

Volume 77, Issue 6, 19 March 2020, Pages 1159-1161
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ATACing DNA Methylation during Differentiation

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Summary

Distal regulatory elements control gene expression during differentiation. In this issue of Molecular Cell, Barnett et al. (2020) develop a new technology, called ATAC-Me, and discover that removal of DNA methylation is not a pre-requisite for the creation of accessible chromatin at active gene regulatory elements during cellular differentiation.

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