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Synthesis 2020; 52(12): 1841-1846
DOI: 10.1055/s-0040-1707996
DOI: 10.1055/s-0040-1707996
paper
Unexpected Iodine-Promoted Aerobic Oxidation of α-Cyano-δ-keto Esters: A Facile Synthesis of α,δ-Dicarbonyl Esters
This work was supported by the Introduction of Talent Research Start-up Fund of Anhui Polytechnic University (2018YQQ015) and Natural Science Foundation for Universities of Anhui Province (KJ2019ZD14).Further Information
Publication History
Received: 04 January 2020
Accepted after revision: 25 February 2020
Publication Date:
16 March 2020 (online)
Abstract
An efficient and green method for the synthesis of various α,δ-dicarbonyl esters has been developed via a conjugate addition of ethyl cyanoacetates to chalcones and subsequent iodine-promoted aerobic oxidation. The present protocol features mild reaction conditions, high efficiency, easily available starting materials, and broad substrate scope.
Key words
cyanoacetates - α,δ-dicarbonyl esters - molecular iodine - aerobic oxidation - two-step synthesisSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1707996.
- Supporting Information
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