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T CELL REPERTOIRE

‘Reverse evolution’ in T cell biology

Comprehensive analysis of CD8+ T cell populations specific to cytomegalovirus reveals that the evolution of the T cell antigen receptor repertoire during chronic infections is characterized by the expansion of low-affinity clones.

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Fig. 1: ‘Reverse evolution’ of TCR during chronic antigen exposure.

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Correspondence to Ramon Arens.

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Redeker, A., Arens, R. ‘Reverse evolution’ in T cell biology. Nat Immunol 21, 360–362 (2020). https://doi.org/10.1038/s41590-020-0639-z

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