Phospholipase D (PLD) regulates various cellular functions through the signaling lipid phosphatidic acid (PA). New crystal structures of human PLD1 and PLD2 reveal a catalytic mechanism, inhibitor binding, and regulation, enabling future structure-based inhibitor design and functional studies of PLD.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Change history
31 March 2020
A Correction to this paper has been published: https://doi.org/10.1038/s41589-020-0527-8
References
Frohman, M. A., Sung, T. C. & Morris, A. J. Biochim. Biophys. Acta 1439, 175–186 (1999).
Brown, H. A., Thomas, P. G. & Lindsley, C. W. Nat. Rev. Drug Discov. 16, 351–367 (2017).
Zhang, Y. & Du, G. Biochim. Biophys. Acta 1791, 850–855 (2009).
Peng, X. & Frohman, M. A. Acta Physiol. (Oxf.) 204, 219–226 (2012).
Nelson, R. K. & Frohman, M. A. J. Lipid Res. 56, 2229–2237 (2015).
Leiros, I., Secundo, F., Zambonelli, C., Servi, S. & Hough, E. Structure 8, 655–667 (2000).
Bowling, F. Z. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-020-0499-8 (2020).
Metrick, C. M. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-019-0458-4 (2020).
Du, G. et al. Mol. Biol. Cell 11, 4359–4368 (2000).
Du, G. et al. J. Cell Biol. 162, 305–315 (2003).
Acknowledgements
The authors acknowledge support from National Institutes of Health (grant # R01AR075830 to G.D.), American Heart Association (grant nos. 19TPA34910051 to G.D. and 18TPA34230046 to L.Z.), and the many scientists whose work and contributions could not be cited due to space limitations.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Zheng, L., Du, G. Illustrating human PLD. Nat Chem Biol 16, 364–365 (2020). https://doi.org/10.1038/s41589-020-0503-3
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41589-020-0503-3