Elsevier

Stem Cell Research

Volume 44, April 2020, 101760
Stem Cell Research

Lab resource: Stem Cell Line
Production and validation of human induced pluripotent stem cell line from sporadic amyotrophic lateral sclerosis (SALS)

https://doi.org/10.1016/j.scr.2020.101760Get rights and content
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Abstract

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with the loss of upper motor neurons in the cortex and lower motor neurons in the brain stem and spinal cord regressively. The vast majority of ALS cases have no familial history are apparently sporadic (SALS), making the modeling of SALS essential to the development of ALS therapeutics. Therefore, human induced pluripotent stem cell (iPSC) from peripheral blood mononuclear cells of a 64-year-old SALS patient were produced using a virus-free protocol and characterized using standard validate methods. This generated iPSC line could be useful to reveal SALS mechanisms and screen drug development.

Keywords

induced pluripotent stem cell
sporadic amyotrophic lateral sclerosis
reprogramming
differentiation

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1

Both the authors contributed equally.