Monolithic microfluidic platform for exerting gradients of compression on cell-laden hydrogels, and application to a model of the articular cartilage
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Carlo Alberto Paggi received his M.S. degree from University of Twente, The Netherlands,in 2018. He is currently doing his Ph.D. at University of Twente. In his Ph.D., he particularly focuses on organ-on-chip devices, microfluidics, and cell biology. He is particularly focused on articular cartilage and osteoarthritis progression.
Bastien Venzac received his Ph.D. degree from the Curie Institute and Pierre et Marie Curie University (Paris, France), in the group of Jean-Louis Viovy and Stephanie Descroix in 2016. His post-doc research focuses on organ-on-chip technology and the development of simple microfluidic technology for biological applications.
Marcel Karperien obtained his Ph.D. at the Netherlands Institute for Developmental Biology and Stem Cell Research. Currently, he is full professor and head of the Department of Developmental BioEngineering group at University of Twente. He is interested in developing new solutions for treating cartilage related disorders. His work is technology inspired and is characterized by a multidisciplinary approach integrating typical engineering disciplines with life-sciences.
Jeroen Leijten received his Ph.D. degree from Twente University in 2012. Currently, he is appointed as an associate professor at Twente University, The Netherlands. His research focuses on the development and application of microtechnological platforms including droplet generators, smart instructive micromaterials, single cell microgels, 3D cellular organoids, 3D printing, and organ-on-chips.
Séverine Le Gac received her Ph.D. degree cum laude from the University of Lille, France, in 2004. She is Professor at the University of Twente, The Netherlands, leading the Applied Microfluidics for BioEngineering Research (AMBER) team. Her research focuses on the use of miniaturized devices for biological and medical applications, and in particular for cancer research and the field of assisted reproductive technologies.
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These authors contributed equally to this work.