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Treatment outcomes of percutaneous radiofrequency ablation versus adrenalectomy for adrenal metastases: a retrospective comparative study

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Abstract

Purpose

To retrospectively evaluate the clinical outcomes of percutaneous ultrasound (US)-guided radiofrequency ablation (RFA) in treatment of adrenal metastasis (AM), and to compare with adrenalectomy (Adx).

Methods

From June 2008 to August 2018, a total of 60 patients with AM treated at our hospital were retrospectively reviewed, of whom 29 treated by RFA (RFA group) and 31 by Adx (Adx group). The technical success, local tumor progression (LTP) and overall survival (OS) after the treatment were evaluated and compared.

Results

In RFA group, the first technical success was 72.4% and the second technical success was 86.2%. In Adx group, all the AMs were successfully resected. After 24.5 ± 19.1 months follow-up period, a total of 8 patients (6 in RFA group and 2 in Adx group) were detected LTP. The 1-, 2- and 3- LTP rates after treatment were 17.1%, 30.9% and 44.7% in RFA group, and 6.5%, 6.5% and 6.5% in Adx group, respectively (P = 0.028). However, for AM ≤ 5 cm, the LTP between the two groups were comparable (P = 0.068). The 1-, 2- and 3- OS rates after treatment for AM were 85.0%, 42.4% and 27.8% in RFA group, and 93.0%, 66.1% and 52.3% in Adx group, respectively (P = 0.057). RFA offered shorter treatment time (23.6 ± 16.9 vs. 155.6 ± 58.8 min, P < 0.001), shorter hospital stay (7.8 ± 3.9 vs. 15.0 ± 4.9 days, P < 0.001), and lower hospital cost ($3405.7 ± 1067.8 vs. $5248.0 ± 2261.3, P = 0.003) than Adx.

Conclusion

In comparison with Adx, percutaneous US-guided RFA, as an alternative treatment, is feasible and effective in controlling AM, especially in AM ≤ 5 cm in diameter.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Grant No. 81701708 and 81530055); Natural Science Foundation of Guangdong Province (Grant No. 2017A030310205); and Training Project for Young Teacher of Sun Yat-sen University (Grant No. 18ykpy10).

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Authors and Affiliations

  1. Division of Interventional Ultrasound, Department of Medical Ultrasound, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhong Shan Road 2, Guangzhou, 510080, China

    B. Liu, W. Wang, C. Jiang, X. Xie, J. Huang, G. Huang, H. Long & X. Xie

  2. Department of Urology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China

    C. Mo

  3. Division of Interventional Ultrasound, Department of Medical Ultrasonics, Foshan First Municipal People’s Hospital (The Affiliated Foshan Hospital of Sun Yat-Sen University), 81 Lingnan North Road, Foshan, 528000, Guangdong, China

    J. Ye

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  1. B. Liu
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Corresponding authors

Correspondence to B. Liu or X. Xie.

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Conflict of interest

The authors state that there is no conflict of interests in the publication of this paper.

Ethical approval

This retrospective study was carried out according to the guidelines of the Helsinki Declaration.

Research involving human participants and/or animals

The study was approved by the Ethical Committee of the First Affiliated Hospital of Sun Yat-sen University (Guangzhou, China).

Informed consent

All the patients signed an informed consent to be enrolled in the study and to perform the RFA procedure.

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Liu, B., Mo, C., Wang, W. et al. Treatment outcomes of percutaneous radiofrequency ablation versus adrenalectomy for adrenal metastases: a retrospective comparative study. J Endocrinol Invest 43, 1249–1257 (2020). https://doi.org/10.1007/s40618-020-01212-w

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  • DOI: https://doi.org/10.1007/s40618-020-01212-w

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