Issue 13, 2020
From the journal:

Chemical Science

Photo-controllable bioorthogonal chemistry for spatiotemporal control of bio-targets in living systems

Jinbo Li, ORCID logo a   Hao Kong, ORCID logo a   Chenghong Zhua  and  Yan Zhang ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Analytical Chemistry for Life Sciences, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China
E-mail: njuzy@nju.edu.cn

Abstract

The establishment of bioorthogonal chemistry is one of the most significant advances in chemical biology using exogenous chemistry to perturb and study biological processes. Photo-modulation of biological systems has realized temporal and spatial control on biomacromolecules in living systems. The combination of photo-modulation and bioorthogonal chemistry is therefore emerging as a new direction to develop new chemical biological tools with spatiotemporal resolution. This minireview will focus on recent development of bioorthogonal chemistry subject to spatiotemporal control through photo-irradiation. Different strategies to realize photo-control on bioorthogonal bond-forming reactions and biological applications of photo-controllable bioorthogonal reactions will be summarized to give a perspective on how the innovations on photo-chemistry can contribute to the development of optochemical biology. Future trends to develop more optochemical tools based on novel photochemistry will also be discussed to envision the development of chemistry-oriented optochemical biology.

Graphical abstract: Photo-controllable bioorthogonal chemistry for spatiotemporal control of bio-targets in living systems

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Article information

DOI
https://doi.org/10.1039/C9SC06540G
Article type
Minireview
Submitted
27 Dec 2019
Accepted
07 Mar 2020
First published
10 Mar 2020
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2020,11, 3390-3396

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Photo-controllable bioorthogonal chemistry for spatiotemporal control of bio-targets in living systems

J. Li, H. Kong, C. Zhu and Y. Zhang, Chem. Sci., 2020, 11, 3390 DOI: 10.1039/C9SC06540G

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