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SYSTEMIC SCLEROSIS

T cells in SSc skin lesions: knowing your enemy

Nature Reviews Rheumatology volume 16, pages 253–254 (2020)Cite this article

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New research suggests that cytotoxic T cells are dominant in the lesional skin of patients with early diffuse cutaneous systemic sclerosis (SSc) and contribute to vasculopathy and tissue fibrosis. Could therapeutic strategies that prevent T cell activation and cytotoxicity therefore present an option to potentially halt progression of SSc?

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Fig. 1: Model for the role of cytotoxic T cells in diffuse cutaneous systemic sclerosis.

References

  1. Denton, C. P. & Khanna, D. Systemic sclerosis. Lancet 390, 1685–1699 (2017).

    PubMed  Google Scholar 

  2. Maehara, T. et al. Cytotoxic CD4+ T lymphocytesmay induce endothelial cell apoptosis in systemic sclerosis. J. Clin. Invest. https://doi.org/10.1172/JCI131700 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Chizzolini, C. & Boin, F. The role of the acquired immune response in systemic sclerosis. Semin. Immunopathol. 37, 519–528 (2015).

    CAS  PubMed  Google Scholar 

  4. Fuschiotti, P. et al. Interleukin-13-producing CD8+ T cells mediate dermal fibrosis in patients with systemic sclerosis. Arthritis Rheum. 65, 236–246 (2013).

    CAS  PubMed Central  PubMed  Google Scholar 

  5. Li, G. et al. Skin-resident effector memory CD8(+)CD28(-) T cells exhibit a profibrotic phenotype in patients with systemic sclerosis. J. Invest. Dermatol. 137, 1042–1050 (2017).

    CAS  PubMed  Google Scholar 

  6. Ayano, M. et al. Increased CD226 expression on CD8+ T cells is associated with upregulated cytokine production and endothelial cell injury in patients with systemic sclerosis. J. Immunol. 195, 892–900 (2015).

    CAS  PubMed  Google Scholar 

  7. McMahan, Z. H. et al. Enrichment of scleroderma vascular disease-associated autoantigens in endothelial lineage cells. Arthritis Rheumatol. 68, 2540–2549 (2016).

    CAS  PubMed Central  PubMed  Google Scholar 

  8. Boleto, G., Allanore, Y. & Avouac, J. Targeting costimulatory pathways in systemic sclerosis. Front. Immunol. 9, 2998 (2018).

    CAS  PubMed Central  PubMed  Google Scholar 

  9. Bosurgi, L. et al. Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells. Science 356, 1072–1076 (2017).

    CAS  PubMed Central  PubMed  Google Scholar 

  10. Lederer, D. J. & Martinez, F. J. Idiopathic pulmonary fibrosis. New Engl. J. Med. 378, 1811–1823 (2018).

    CAS  PubMed  Google Scholar 

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  1. Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Patrizia Fuschiotti

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  1. Patrizia Fuschiotti
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Correspondence to Patrizia Fuschiotti.

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Fuschiotti, P. T cells in SSc skin lesions: knowing your enemy. Nat Rev Rheumatol 16, 253–254 (2020). https://doi.org/10.1038/s41584-020-0404-6

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