Mind the Gapmer: Implications of Co-transcriptional Cleavage by Antisense Oligonucleotides

doi:10.1016/j.molcel.2020.02.010

Molecular Cell

Volume 77, Issue 5, 5 March 2020, Pages 932-933

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While gapmers efficiently knock down as well as terminate transcription of nascent lncRNAs and mRNAs, Lee and Mendell (2020) and Lai et al. (2020) also demonstrate that Pol II termination is not observed with gapmers targeting the 3′ terminal portions of the transcript.

Molecular Cell

PreviewMind the Gapmer: Implications of Co-transcriptional Cleavage by Antisense Oligonucleotides

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Mind the Gapmer: Implications of Co-transcriptional Cleavage by Antisense Oligonucleotides