Whether adult humans continue to produce new neurons remains controversial. Here, Durante et al. sampled olfactory neuroepithelium from seven healthy middle-aged people, and used single-cell RNA sequencing and immunohistochemistry to determine cellular heterogeneity and maturation stage. They observed cells from all stages of differentiation, from stem cells to mature neurons, with a surprisingly high 55% of the cells expressing immature markers. These data suggest that the olfactory neuroepithelium is a site of ongoing neurogenesis in adult humans.
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Durante, M. A. et al. Single-cell analysis of olfactory neurogenesis and differentiation in adult humans. Nat. Neurosci. https://doi.org/10.1038/s41593-020-0587-9 (2020)
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Lewis, S. New nose neurons. Nat Rev Neurosci 21, 182 (2020). https://doi.org/10.1038/s41583-020-0283-5
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DOI: https://doi.org/10.1038/s41583-020-0283-5
