The role of ADP-ribose metabolism in metabolic regulation, adipose tissue differentiation, and metabolism
- 1Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen 4032, Hungary;
- 2MTA-DE Lendület Laboratory of Cellular Metabolism, University of Debrecen, Debrecen 4032, Hungary;
- 3Research Center for Molecular Medicine, Faculty of Medicine, University of Debrecen, Debrecen 4032, Hungary
- Corresponding author: baip{at}med.unideb.hu
Abstract
Poly(ADP-ribose) polymerases (PARPs or ARTDs), originally described as DNA repair factors, have metabolic regulatory roles. PARP1, PARP2, PARP7, PARP10, and PARP14 regulate central and peripheral carbohydrate and lipid metabolism and often channel pathological disruptive metabolic signals. PARP1 and PARP2 are crucial for adipocyte differentiation, including the commitment toward white, brown, or beige adipose tissue lineages, as well as the regulation of lipid accumulation. Through regulating adipocyte function and organismal energy balance, PARPs play a role in obesity and the consequences of obesity. These findings can be translated into humans, as evidenced by studies on identical twins and SNPs affecting PARP activity.
Keywords
- PARP
- ARTD
- adipocyte
- adipogenesis
- mitochondria
- lipolysis
- differentiation
- white adipocytes
- brown adipocytes
- beige adipocytes
- stem cell
- PARylation
- high fat diet
- obesity
- insulin resistance
- AFLD
- NAFLD
- atherosclerosis
Footnotes
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Article published online ahead of print. Article and publication date are online at http://www.genesdev.org/cgi/doi/10.1101/gad.334284.119.
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Freely available online through the Genes & Development Open Access option.
This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.
