Original ResearchA Physiology-Based Model of Bile Acid Distribution and Metabolism Under Healthy and Pathologic Conditions in Human Beings
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CRedit Authorship Contributions Veronika Voronova, PharmD (Conceptualization: Equal; Data curation: Equal; Formal analysis: Lead; Investigation: Lead; Writing – original draft: Lead) Victor Sokolov, MSc (Formal analysis: Supporting; Investigation: Supporting; Validation: Equal; Writing – original draft: Supporting) Amani Al-Khaifi, PhD (Data curation: Equal; Formal analysis: Equal; Writing – review & editing: Supporting) Sara Straniero, PhD (Formal analysis: Supporting; Writing – review & editing: Supporting) Chanchal Kumar, PhD (Funding acquisition: Supporting; Project administration: Equal; Writing – review & editing: Supporting) Kirill Peskov, PhD (Conceptualization: Supporting; Funding acquisition: Supporting; Project administration: Supporting; Supervision: Equal; Writing – original draft: Supporting) Gabriel Helmlinger, PhD (Project administration: Supporting; Supervision: Supporting; Writing – original draft: Supporting) Mats Rudling, MD, PhD (Conceptualization: Equal; Formal analysis: Supporting; Funding acquisition: Supporting; Writing – review & editing: Equal) Bo Angelin, MD, PhD (Conceptualization: Equal; Formal analysis: Equal; Funding acquisition: Lead; Resources: Equal; Writing – review & editing: Lead).
Conflicts of interest Chanchal Kumar and Gabriel Helmlinger are employees of AstraZeneca Pharmaceuticals and may own shares; Kirill Peskov is the owner of M&S Decisions, LLC, and Veronika Voronova and Victor Sokolov are employees of M&S Decisions, LLC, a modeling research consultancy contracted by AstraZeneca Pharmaceuticals; Bo Angelin serves as a consultant to Albireo AB and has received unrelated grant support from Amgen. The remaining authors disclose no conflicts.
Funding This work was supported by AstraZeneca Pharmaceuticals, the Swedish Heart-Lung Foundation, the Swedish Research Council, the Cardiovascular Program of Karolinska Institutet/Stockholm County Council, the Knut and Alice Wallenberg Foundation, Sultan Qaboos University (3791/2012), the Leducq Foundation, and the Russian Academic Excellence Project 5-100 program.