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Application of vitamin-producing lactic acid bacteria to treat intestinal inflammatory diseases

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Abstract

Recent studies have shown that inflammatory diseases are becoming more frequent throughout the world. The causes of these disorders are multifactorial and include genetic, immunological, and environmental factors, and intestinal microbiota dysbiosis. The use of beneficial microorganisms has shown to be useful in the prevention and treatment of disorders such as colitis, mucositis, and even colon cancer by their immune-stimulating properties. It has also been shown that certain vitamins, especially riboflavin and folate derivatives, have proven to be helpful in the treatment of these diseases. The application of vitamin-producing lactic acid bacteria, especially strains that produce folate and riboflavin together with immune-stimulating strains, could be used as adjunct treatments in patients suffering from a wide range of inflammatory diseases since they could improve treatment efficiency and prevent undesirable side effects in addition to their nutrition values. In this review, the most up to date information on the current knowledge and uses of vitamin-producing lactic acid bacteria is discussed in order to stimulate further studies in this field.

Key Points

• Probiotic lactic acid bacteria possess anti-inflammatory properties

• Vitamin-producing strains can reduce intestinal inflammation

• Probiotic blends can complement anti-inflammatory treatments

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Funding

This work was supported by CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas projects PIP 0697), the ANPCyT (Agencia Nacional de Promoción Científica y Tecnológica projects 0301 and 2554), and the Ibero-American Program of Science and Technology for the Development (CYTED, Strategic Project Ref: 917PTE0537).

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  1. Jean Guy LeBlanc and Alejandra de Moreno de LeBlanc contributed equally to this work.

Authors and Affiliations

  1. Centro de Referencia para Lactobacilos (CERELA-CONICET), Chacabuco 145, T4000ILC, San Miguel de Tucumán, Tucumán, Argentina

    Jean Guy LeBlanc, Romina Levit, Graciela Savoy de Giori & Alejandra de Moreno de LeBlanc

  2. Cátedra de Microbiología Superior, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, San Miguel de Tucumán, Tucumán, Argentina

    Graciela Savoy de Giori

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  1. Jean Guy LeBlanc
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All authors wrote the manuscript, made critical revisions of the manuscript, and approved the final version of the manuscript.

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LeBlanc, J.G., Levit, R., Savoy de Giori, G. et al. Application of vitamin-producing lactic acid bacteria to treat intestinal inflammatory diseases. Appl Microbiol Biotechnol 104, 3331–3337 (2020). https://doi.org/10.1007/s00253-020-10487-1

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