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PATHBIO: an international training program for precision mouse phenotyping

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Abstract

Design and production of genetically engineered mouse strains by individual research laboratories, research teams, large-scale consortia, and the biopharmaceutical industry have magnified the need for qualified personnel to identify, annotate, and validate (phenotype) these potentially new mouse models of human disease. The PATHBIO project has been recently established and funded by the European Union’s ERASMUS+ Knowledge Alliance program to address the current shortfall in formally trained personnel. A series of teaching workshops will be given by experts on anatomy, histology, embryology, imaging, and comparative pathology to increase the availability of individuals with formal training to contribute to this important niche of Europe’s biomedical research enterprise. These didactic and hands-on workshops are organized into three modules: (1) embryology, anatomy, histology, and the anatomical basis of imaging, (2) image-based phenotyping, and (3) pathology. The workshops are open to all levels of participants from recent graduates to Ph.D., M.D., and veterinary scientists. Participation is available on a competitive basis at no cost for attending. The first series of Workshop Modules was held in 2019 and these will continue for the next 2 years.

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Acknowledgements

This work was supported by a grant from the Erasmus+ Knowledge Alliance of the Education, Audiovisual and Culture Executive Agency (EACEA) of the European Union (Reference Number 600803-EPP-1-2018-1-ES-EPPKA2). The name of the project is Precision PathoBiology for Disease Models (PATHBIO). The authors want also to thank all partners involved in the PATHBIO Consortium.

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Authors and Affiliations

  1. Center for Animal Biotechnology and Gene Therapy, Department of Animal Health and Anatomy, Universitat Autònoma de Barcelona, Barcelona, Spain

    Jesus Ruberte & Guillem Gracia

  2. University of Cambridge, Cambridge, UK

    Paul N. Schofield

  3. Biotech Research & Innovation Centre, Univerisity of Copenhagen, Copenhagen, Denmark

    Cord Brakebusch

  4. St. Jude Children’s Research Hospital, Memphis, TN, USA

    Peter Vogel

  5. Centre Européen de Recherche en Biologie et en Medicine, Institut Clinique de la Souris, Illkirch, France

    Yann Herault

  6. The Hospital for Sick Children and The Center for Phenogenomics, Toronto, Canada

    Colin McKerlie

  7. Helmholtz Zentrum Muenchen Deustsches Forschungszentrum fuer Gesundheit und Umwelt GMBH, Munich, Germany

    Martin Hrabĕ de Angelis & Michael Hagn

  8. The Jackson Laboratory, Bar Harbor, ME, USA

    Paul N. Schofield & John P. Sundberg

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  1. Jesus Ruberte
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  2. Paul N. Schofield
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  3. Cord Brakebusch
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  8. Martin Hrabĕ de Angelis
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  9. Michael Hagn
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  10. John P. Sundberg
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Correspondence to Jesus Ruberte.

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Ruberte, J., Schofield, P.N., Brakebusch, C. et al. PATHBIO: an international training program for precision mouse phenotyping. Mamm Genome 31, 49–53 (2020). https://doi.org/10.1007/s00335-020-09829-1

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  • DOI: https://doi.org/10.1007/s00335-020-09829-1

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