Skip to main content

Advertisement

Log in

Minimally Invasive Lumbar Decompression and Interspinous Process Device for the Management of Symptomatic Lumbar Spinal Stenosis: a Literature Review

  • Other Pain (AD Kaye and N Vadivelu, Section Editors)
  • Published:
Current Pain and Headache Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Symptomatic lumbar spinal stenosis (LSS) is a condition affecting a growing number of individuals resulting in significant disability and pain. Traditionally, treatment options have consisted of conservative measures such as physical therapy, medication management, epidural injections and percutaneous adhesiolysis, or surgery. There exists a treatment gap for patients failing conservative measures who are not candidates for surgery. Minimally invasive lumbar decompression (MILD®) and interspinous process device (IPD) with Superion® represent minimally invasive novel treatment options that may help fill this gap in management. We performed a literature review to separately evaluate these procedures and assess the effectiveness and safety.

Recent Findings

The available evidence for MILD and Superion has been continuously debated. Overall, it is considered that while the procedures are safe, there is only modest evidence for effectiveness.

Summary

For both procedures, we have reviewed 13 studies. Based on the available evidence, MILD and Superion are safe and modestly effective minimally invasive procedures for patients with symptomatic LSS. It is our recommendation that these procedures may be incorporated as part of the continuum of treatment options for patients meeting clinical criteria.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Lurie J, Tomkins-Lane C. Management of lumbar spinal stenosis. BMJ. 2016;352:h6234.

    PubMed  PubMed Central  Google Scholar 

  2. Postacchini F. Management of lumbar spinal stenosis. J Bone Joint Surg Br. 1996;78:154–64.

    CAS  PubMed  Google Scholar 

  3. • Costandi S, Chopko B, Mekhail M, Dews T, Mekhail N. Lumbar spinal stenosis: therapeutic options review. Pain Pract. 2015;15:68–81 (excellent review of therapeutic options for lumbar spinal stenosis).

    PubMed  Google Scholar 

  4. Hillson B. Population reference bureau. Coll Res Libr News. 2003;64:760–1.

    Google Scholar 

  5. Smith M, Davis MA, Stano M, Whedon JM. Aging baby boomers and the rising cost of chronic back pain: secular trend analysis of longitudinal medical expenditures panel survey data for years 2000 to 2007. J Manip Physiol Ther. 2013;36:2–11.

    Google Scholar 

  6. •• Manchikanti L, Kaye AD, Manchikanti KN, Boswell MV, Pampati V, Hirsch JA. Efficacy of epidural injections in the treatment of lumbar central spinal stenosis: A systematic review. Anesth Pain Med. 2015;5:e23139 (excellent review of efficacy of epidural injections for lumbar spinal stenosis).

    PubMed  PubMed Central  Google Scholar 

  7. Manchikanti L, Knezevic NN, Boswell MV, Kaye AD, Hirsch JA. Epidural injections for lumbar radiculopathy and spinal stenosis: a comparative systematic review and meta-analysis. Pain Physician 2016;E365410.

  8. Shen J, Xu S, Xu S, Ye S, Hao J. Fusion or not for degenerative lumbar spinal stenosis: a meta-analysis and systematic review. Pain Physician. 2018;21:1–8.

    PubMed  Google Scholar 

  9. Chang MC, Lee DG. Outcome of transforaminal epidural steroid injection according to the severity of lumbar foraminal spinal stenosis. Pain Physician. 2018;21:67–72.

    PubMed  Google Scholar 

  10. Jeon JY, Jeong YM, Lee SW, Kim JH, Choi HY, Ahn Y. The termination level of the dural sac relevant to caudal epidural block in lumbosacral transitional vertebrae: a comparison between sacralization and lumbarization groups. Pain Physician. 2018 21(1):73-82.

  11. Artemiadis AK, Zis P. Neuropathic pain in acute and subacute neuropathies: a systematic review. Pain Physician. 2018;21:111–20.

    PubMed  Google Scholar 

  12. Zadro JR, Shirley D, Ferreira M, Carvalho Silva AP, Lamb SE, Cooper C, et al. Is vitamin d supplementation effective for low back pain? A systematic review and meta-analysis. Pain Physician. 2018;21:121–45.

    PubMed  Google Scholar 

  13. Zhou C, Zhang G, Panchal RR, Ren X, Xiang H, Xuexiao M, et al. Unique complications of percutaneous endoscopic lumbar discectomy and percutaneous endoscopic interlaminar discectomy. Pain Physician. 2018;21:E105–12.

    PubMed  Google Scholar 

  14. Makkar JK, Kumar B, Jain K, Dhutt SS, Batra YK, Singh PM. Effect of different volumes on pain relief in patient receiving fluoroscopic guided interlaminar lumbar epidural steroid injection. Pain Physician. 2018;21:243–50.

    PubMed  Google Scholar 

  15. Kim WJ, Shin HY, Yoo SH, Park HS. Comparison of epidural spreading patterns and clinical outcomes of transforaminal epidural steroid injection with high-volume injectate via the subpedicular versus the retrodiscal approach. Pain Physician. 2018;21:269–78.

    PubMed  Google Scholar 

  16. Sanchis-Lopez N, Romero-Garcia C, De Andres-Ibanez J, Martinez-Plumed R, Rodriguez-Gimillo P, Hernandez-Cadiz MJ, et al. Medical device related pressure injury in the treatment of chronic pain: an early sign of explantation in suspected infection. Pain Physician. 2018;21:E235–46.

    PubMed  Google Scholar 

  17. Manchikanti L, Kaye AM, Knezevic NN, McAnally H, Trescot AM, Blank S, et al. Responsible, safe, and effective prescription of opioids for chronic non-cancer pain: American Society of Interventional Pain Physicians (ASIPP) guidelines. Pain Physician. 2017;20(2S):S3–92.

    PubMed  Google Scholar 

  18. Jonan AB, Kaye AD, Urman RD. Buprenorphine formulations: clinical best practice strategies recommendations for perioperative management of patients undergoing surgical or interventional pain procedures. Pain Physician. 2018;21:E1–12.

    PubMed  Google Scholar 

  19. Chen JH, Wu SC, Muo CH, Kao CH, Tseng CH, Tsai CH. Association of higher migraine risk among female and younger chronic osteomyelitis patients: evidence from a Taiwan cohort of one million. Pain Physician. 2018;21:E149–56.

    PubMed  Google Scholar 

  20. Fischer B, Jones W, Vojtila L, Kurdyak P. Patterns, changes, and trends in prescription opioid dispensing in Canada, 2005-2016. Pain Physician. 2018;21:219–28.

    PubMed  Google Scholar 

  21. Manchikanti L, Sanapati J, Benyamin RM, Atluri S, Kaye AD, Hirsch JA. Reframing the prevention strategies of the opioid crisis: focusing on prescription opioids, fentanyl, and heroin epidemic. Pain Physician. 2018;21:309–26.

    PubMed  Google Scholar 

  22. Dexter P, Warvel J, Takesue B. Identifying dominant inpatient trends leveraging electronic physician orders: the medical gopher 1993-2016. AMIA Annu Symp Proc. 2018;2018:377–84.

    PubMed  PubMed Central  Google Scholar 

  23. Bansal D, Boya CS, Vatte R, Ghai B. High prevalence of hypovitaminosis d in patients with low back pain: evidence from meta-analysis. Pain Physician. 2018;21:E389–99.

    PubMed  Google Scholar 

  24. Roldan CJ, Johnson C, Lee SO, Peng A, Dougherty PM, Huh B. Subclinical peripheral neuropathy in patients with head and neck cancer: a quantitative sensory testing (QST) study. Pain Physician. 2018;21:E419–27.

    PubMed  PubMed Central  Google Scholar 

  25. Nah SY, Lee JH, Lee JH. Effects of epidural steroid injections on bone mineral density and bone turnover markers in patients taking anti-osteoporotic medications. Pain Physician. 2018;21:E435–47.

    PubMed  Google Scholar 

  26. Manchikanti L, Singh V, Benyamin RM, Kaye AD, Pampati V, Hirsch JA. Reframing medicare physician payment policy for 2019: a look at proposed policy. Pain Physician. 2018;21:415–32.

    PubMed  Google Scholar 

  27. Doan L, Patel H, Aronova Y, Gharibo C. Variations in interlaminar epidural steroid injection practice patterns by interventional pain management physicians in the United States. Pain Physician. 2018;21:E493–9.

    PubMed  Google Scholar 

  28. Romman A, Salama-Hanna J, Dwivedi S. Mexiletine usage in a chronic pain clinic: indications, tolerability, and side effects. Pain Physician. 2018;21:E573–9.

    PubMed  Google Scholar 

  29. Chakravarthy K, Manchikanti L, Kaye AD, Christo PJ. Reframing the role of neuromodulation therapy in the chronic pain treatment paradigm. Pain Physician. 2018;21:507–13.

    PubMed  Google Scholar 

  30. Sanapati J, Manchikanti L, Atluri S, Jordan S, Albers SL, Pappolla MA, et al. Do regenerative medicine therapies provide long-term relief in chronic low back pain: a systematic review and metaanalysis. Pain Physician. 2018;21:515–40.

    PubMed  Google Scholar 

  31. Orhan C, Van Looveren E, Cagnie B, Mukhtar NB, Lenoir D, Meeus M. Are pain beliefs, cognitions, and behaviors influenced by race, ethnicity, and culture in patients with chronic musculoskeletal pain: a systematic review. Pain Physician. 2018;21:541–58.

    PubMed  Google Scholar 

  32. Karm MH, Choi SS, Kim DH, Park JY, Lee S, Park JK, et al. Percutaneous epidural adhesiolysis using inflatable balloon catheter and balloon-less catheter in central lumbar spinal stenosis with neurogenic claudication: a randomized controlled trial. Pain Physician. 2018;21:593–606.

    PubMed  Google Scholar 

  33. Patwardhan A, Matika R, Gordon J, Singer B, Salloum M, Ibrahim M. Exploring the role of chronic pain clinics: potential for opioid reduction. Pain Physician. 2018;21:E603–10.

    PubMed  Google Scholar 

  34. Lee JH, Shin KS, Park SJ, Lee GJ, Lee CH, Kim DH, et al. Comparison of clinical efficacy between transforaminal and interlaminar epidural injections in lumbosacral disc herniation: a systematic review and meta-analysis. Pain Physician. 2018;21:433–48.

    PubMed  Google Scholar 

  35. Lee JH, Kim DH, Kim DH, Shin KS, Park SJ, Lee GJ, et al. Comparison of clinical efficacy of epidural injection with or without steroid in lumbosacral disc herniation: a systematic review and meta-analysis. Pain Physician. 2018;21:449–68.

    PubMed  Google Scholar 

  36. Manchikanti L, Pampati V, Benyamin RM, Hirsch JA. Declining utilization of percutaneous epidural adhesiolysis in Medicare population: evidence-based or over-regulated? IPM Reports. 2018;2:9–18.

    Google Scholar 

  37. Manchikanti L, Soin A, Mann DP, Bakshi S, Pampati V, Hirsch JA. Reversal of growth of utilization of interventional techniques in managing chronic pain in Medicare population post affordable care act. Pain Physician. 2017;20:551–67.

    PubMed  Google Scholar 

  38. Manchikanti L, Soin A, Mann DP, Bakshi S, Pampai V, Hirsch JA. Comparative analysis of utilization of epidural procedures in managing chronic pain in the Medicare population: pre and post affordable care act. Spine (Phila Pa 1976). 2019;44:220–32.

    Google Scholar 

  39. Zaina F, Tomkins-Lane C, Carragee E, Negrini S. Surgical versus non-surgical treatment for lumbar spinal stenosis. Cochrane Database Syst Rev. 2016:CD010264.

  40. Helm S II, Racz GB, Gerdesmeyer L, Justiz L, Hayek SM, Kaplan ED, et al. Percutaneous and endoscopic adhesiolysis in managing low back and lower extremity pain: a systematic review and meta-analysis. Pain Physician. 2016;19:E245–82.

    PubMed  Google Scholar 

  41. Machado GC, Ferreira PH, Yoo RI, Harris IA, Pinheiro MB, Koes BW, et al. Surgical options for lumbar spinal stenosis. Cochrane Database Syst Rev. 2016;11:CD012421.

    PubMed  Google Scholar 

  42. Chang W, Yuwen P, Zhu Y, Wei N, Feng C, Zhang Y, et al. Effectiveness of decompression alone versus decompression plus fusion for lumbar spinal stenosis: a systematic review and meta-analysis. Arch Orthop Trauma Surg. 2017;137:637–50.

    PubMed  Google Scholar 

  43. Scholler K, Alimi M, Cong GT, Christos P, Hartl R. Lumbar spinal stenosis associated with degenerative lumbar spondylolisthesis: a systematic review and meta-analysis of secondary fusion rates following open vs minimally invasive decompression. Neurosurgery. 2017;80:355–67.

    PubMed  Google Scholar 

  44. Murphy ME, Gilder H, Maloney PR, McCutcheon BA, Rinaldo L, Shepherd D, et al. Lumbar decompression in the elderly: increased age as a risk factor for complications and nonhome discharge. J Neurosurg Spine. 2017;26:353–62.

    PubMed  Google Scholar 

  45. •• Staats PS, Chafin TB, Golovac S, Kim CK, Li S, Richardson WB, et al. MiDAS ENCORE Investigators. Long-term safety and efficacy of minimally invasive lumbar decompression procedure for the treatment of lumbar spinal stenosis with neurogenic claudication: 2-year results of MiDAS ENCORE. Reg Anesth Pain Med. 2018;43:789–94 (excellent study on safety and efficacy of MILD procedure for lumbar spinal stenosis, two year results).

    PubMed  PubMed Central  Google Scholar 

  46. Benyamin RM, Staats PS, MIDAS Encore I. MILD® is an effective treatment for lumbar spinal stenosis with neurogenic claudication: MiDAS ENCORE randomized controlled trial. Pain Physician. 2016;19:229–42.

    PubMed  Google Scholar 

  47. Brown LL. A double-blind, randomized, prospective study of epidural steroid injection vs. the mild® procedure in patients with symptomatic lumbar spinal stenosis. Pain Pract. 2012;12:333–41.

    PubMed  Google Scholar 

  48. Mekhail N, Vallejo R, Coleman MH, Benyamin RM. Long-term results of percutaneous lumbar decompression mild(®) for spinal stenosis. Pain Pract. 2012;12:184–93.

    PubMed  Google Scholar 

  49. Durkin B, Romeiser J, Shroyer AL, Schiller R, Bae J, Davis RP, et al. Report from a quality assurance program on patients undergoing the MILD procedure. Pain Med. 2013;14:650–6.

    PubMed  Google Scholar 

  50. Wilkinson JS, Fourney DR. Failure of percutaneous remodeling of the ligamentum flavum and lamina for neurogenic claudication. Neurosurgery. 2012;71:86–92.

    PubMed  Google Scholar 

  51. Wang JJ, Bowden K, Pang G, Cipta A. Decrease in health care resource utilization with MILD. Pain Med. 2013;14:657–61.

    PubMed  Google Scholar 

  52. Lingreen R, Grider JS. Retrospective review of patient self-reported improvement and post-procedure findings for mild (minimally invasive lumbar decompression). Pain Physician. 2010;13:555–60.

    PubMed  Google Scholar 

  53. Deer TR, Kim CK, Bowman RG 2nd, Ranson MT, Yee BS. Study of percutaneous lumbar decompression and treatment algorithm for patients suffering from neurogenic claudication. Pain Physician. 2012;15:451–60.

    PubMed  Google Scholar 

  54. Nunley PD, Patel VV, Orndorff DG, Lavelle WF, Block JE, Geisler FH. Five-year durability of stand-alone interspinous process decompression for lumbar spinal stenosis. Clin Interv Aging. 2017;12:1409–17.

    PubMed  PubMed Central  Google Scholar 

  55. Patel VV, Whang PG, Haley TR, Bradley WD, Nunley PD, Davis RP, et al. Superion interspinous process spacer for intermittent neurogenic claudication secondary to moderate lumbar spinal stenosis: two-year results from a randomized controlled FDA-IDE pivotal trial. Spine (Phila Pa 1976). 2015;40:275–82.

    Google Scholar 

  56. Nunley PD, Deer TR, Benyamin RM, Staats PS, Block JE. Interspinous process decompression is associated with a reduction in opioid analgesia in patients with lumbar spinal stenosis. J Pain Res. 2018;11:2943–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  57. Nunley PD, Patel VV, Orndorff DG, Lavelle WF, Block JE, Geisler FH. Interspinous process decompression improves quality of life in patients with lumbar spinal stenosis. Minim Invasive Surg. 2018;2018:1035954.

    PubMed  PubMed Central  Google Scholar 

  58. Shabat S, Miller LE, Block JE, Gepstein R. Minimally invasive treatment of lumbar spinal stenosis with a novel interspinous spacer. Clin Interv Aging. 2011;6:227–33.

    PubMed  PubMed Central  Google Scholar 

  59. Bini W, Miller LE, Block JE. Minimally invasive treatment of moderate lumbar spinal stenosis with the Superion® interspinous spacer. Open Orthop J. 2011;5:361–7.

    PubMed  PubMed Central  Google Scholar 

  60. Center for Evidence-Based Policy, Oregon Health & Science University. Interlaminar/Interspinous process distraction devices for neurogenic claudication or lumbar spinal stenosis (CPT codes 22867/22870). 2017, Revised August 7, 2017.

  61. North American Spine Society. Evidence-based clinical guidelines for multidisciplinary spine care. Diagnosis and Treatment of Degenerative Lumbar Spinal Stenosis 2011. https://www.spine.org/Portals/0/assets/downloads/ResearchClinicalCare/Guidelines/LumbarStenosis.pdf

  62. North American Spine Society. NASS coverage policy recommendations. Interspinous Device without Fusion. December 4, 2014. Available at: https://www.spine.org/Product-Details?productid=%7B512DD0BB-764D-E811-8121-0050569159BF%7D. Accessed 7 Feb 2020.

  63. Shanthanna H, Busse JW, Thabane L, Paul J, Couban R, Choudhary H, et al. Local anesthetic injections with or without steroid for chronic non-cancer pain: a protocol for a systematic review and meta-analysis of randomized controlled trials. Syst Rev. 2016;5:18.

    PubMed  PubMed Central  Google Scholar 

  64. Manchikanti L, Nampiaparampil DE, Manchikanti KN, Falco FJE, Singh V, Benyamin RM, et al. Comparison of the efficacy of saline, local anesthetics, and steroids in epidural and facet joint injections for the management of spinal pain: a systematic review of randomized controlled trials. Surg Neurol Int. 2015;6:S194–235.

    PubMed  PubMed Central  Google Scholar 

  65. Chou R, Hashimoto R, Friedly J, Fu R, Bougatsos C, Dana T, et al. Epidural corticosteroid injections for radiculopathy and spinal stenosis: a systematic review and meta-analysis. Ann Intern Med. 2015;163:373–81.

    PubMed  Google Scholar 

  66. Lewis R, Williams N, Matar HE, Din N, Fitzsimmons D, Phillips C, et al. The clinical effectiveness and cost effectiveness of management strategies for sciatica: systematic review and economic model. Health Technol Assess. 2011;15:1–578.

    CAS  PubMed  PubMed Central  Google Scholar 

  67. Lewis RA, Williams NH, Sutton AJ, Burton K, Din NU, Matar HE, et al. Comparative clinical effectiveness of management strategies for sciatica: systematic review and network meta-analyses. Spine J. 2015;15:1461–77.

    PubMed  Google Scholar 

  68. Guo JR, Jin XJ, Shen HC, Wang H, Zhou X, Liu XQ, et al. A comparison of the efficacy and tolerability of the treatments for sciatica: a network meta-analysis. Ann Pharmacother. 2017;51:1041–52.

    CAS  PubMed  Google Scholar 

  69. Manchikanti L, Pampati V, Benyamin RM, Boswell MV. Analysis of efficacy differences between caudal and lumbar interlaminar epidural injections in chronic lumbar axial discogenic pain: local anesthetic alone vs. local combined with steroids. Int J Med Sci. 2015;12:214–22.

    CAS  PubMed  PubMed Central  Google Scholar 

  70. Manchikanti L, Singh V, Pampati V, Falco FJE, Hirsch JA. Comparison of the efficacy of caudal, interlaminar, and transforaminal epidural injections in managing lumbar disc herniation: is one method superior to the other? Korean J Pain. 2015;28:11–21.

    PubMed  PubMed Central  Google Scholar 

  71. Manchikanti L, Benyamin RM, Falco FJ, Kaye AD, Hirsch JA. Do epidural injections provide short- and long-term relief for lumbar disc herniation? A systematic review. Clin Orthop Relat Res. 2015;473:1940–56.

    PubMed  Google Scholar 

  72. Pinto RZ, Maher CG, Ferreira ML, Hancock M, Oliveira VC, McLachlan AJ, et al. Epidural corticosteroid injections in the management of sciatica: a systematic review and meta-analysis. Ann Intern Med. 2012;157:865–77.

    PubMed  Google Scholar 

  73. Bicket M, Gupta A, Brown CH, Cohen SP. Epidural injections for spinal pain: a systematic review and meta-analysis evaluating the “control” injections in randomized controlled trials. Anesthesiology. 2013;119:907–31.

    PubMed  Google Scholar 

  74. Eden J, Levit L, Berg A, Morton S. Committee on Standards for Systematic Reviews of Comparative Effectiveness Research; Institute of Medicine. Finding What Works in Health Care. In: Standards for Systematic Reviews. Washington: The National Academies Press; 2011.

    Google Scholar 

  75. Flier JS. Conflict of interest among medical school faculty: achieving a coherent and objective approach. JAMA. 2017;317:1731–2.

    PubMed  Google Scholar 

  76. Cappola AR, FitzGerald GA. Confluence, not conflict of interest: name change necessary. JAMA. 2015;314:1791–2.

    CAS  PubMed  Google Scholar 

  77. Greenhalgh T, Howick J, Maskrey N; Evidence Based Medicine Renaissance Group. Evidence based medicine: a movement in crisis? BMJ 2014;348:g3725.

  78. Rysavy M. Evidence-based medicine: a science of uncertainty and an art of probability. AMA J Ethics. 2013;15:4–8.

    Google Scholar 

  79. Djulbegovic B, Guyatt G. Evidence vs consensus in clinical practice guidelines. JAMA 2019.

  80. Guyatt G, Gutterman D, Baumann MH, Addrizzo-Harris D, Hylek EM, Phillips B, et al. Grading strength of recommendations and quality of evidence in clinical guidelines. Report from an American College of Chest Physicians task force. Chest. 2006;129:174–81.

    PubMed  Google Scholar 

  81. Foroutan F, Guyatt G, Alba AC, Ross H. Meta-analysis: mistake or milestone in medicine? Heart. 2018;104:1559–61.

    PubMed  Google Scholar 

  82. Manchikanti L, Knezevic NN, Sanapati J, Kaye AD, Sanapati M, Hirsch JA. Is epidural injection of sodium chloride solution a true placebo or an active control agent? Curr Pain Headache Rep: A systematic review and meta-analysis; 2019. in press

    Google Scholar 

  83. Manchikanti L, Knezevic NN, Parr A III, Kaye AD, Sanapati M, Hirsch JA. Does epidural bupivacaine with or without steroids provide long-term relief? Curr Pain Headache Rep: A systematic review and meta-analysis; 2019. in press

    Google Scholar 

  84. Manchikanti L, Soin A, Boswell MV, Kaye AD, Sanapati M, Hirsch JA. Effectiveness of percutaneous adhesiolysis in post lumbar surgery syndrome: a systematic analysis of findings of systematic reviews. Pain Physician. 2019;22:307–22.

    PubMed  Google Scholar 

  85. Deer TR, Grider JS, Pope JE, Falowski S, Lamer TJ, Calodney A, et al. The MIST guidelines: the lumbar spinal stenosis consensus group guidelines for minimally invasive spine treatment. Pain Pract. 2019;19:250–74.

    PubMed  Google Scholar 

Download references

Acknowledgments

David Lee Osterbur, PhD, MLIS

Director of Entrepreneurial Ventures & Director of Harvard Library of Evidence

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Richard D. Urman.

Ethics declarations

Conflict of Interest

Justin Merkow, Narayana Varhabhatla, Laxmaiah Manchikanti, Richard D. Urman and Jason Yong declare no conflict of interest. Alan Kaye is a Section Editor for Current Headache and Pain Reports. He has not been involved in the editorial handling of this manuscript. Dr. Kaye is also a speaker for Merck.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the Topical Collection on Other Pain

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Merkow, J., Varhabhatla, N., Manchikanti, L. et al. Minimally Invasive Lumbar Decompression and Interspinous Process Device for the Management of Symptomatic Lumbar Spinal Stenosis: a Literature Review. Curr Pain Headache Rep 24, 13 (2020). https://doi.org/10.1007/s11916-020-0845-2

Download citation

  • Published:

  • DOI: https://doi.org/10.1007/s11916-020-0845-2

Keywords

Navigation