Abstract
Extracorporeal CO2 removal is a highly promising support therapy for patients with hypercapnic respiratory failure but whose clinical implementation and patient benefit is hampered by high cost and highly specialized expertise required for safe use. Current approaches target removal of the gaseous CO2 dissolved in blood which limits their ease of clinical use as high blood flow rates are required to achieve physiologically significant CO2 clearance. Here, a novel hybrid approach in which a zero-bicarbonate dialysis is used to target removal of bicarbonate ion coupled to a gas exchange device to clear dissolved CO2, achieves highly efficiently total CO2 capture while maintaining systemic acid–base balance. In a porcine model of acute hypercapnic respiratory failure, a CO2-reduction of 61.4 ± 14.4 mL/min was achieved at a blood flow rate of 248 mL/min using pediatric-scale priming volumes. The dialyzer accounted for 81% of total CO2 capture with an efficiency of 33% with a minimal pH change across the entire circuit. This study demonstrates the feasibility of a novel hybrid CO2 capture approach capable of achieving physiologically significant CO2 removal at ultralow blood flow rates with low priming volumes while leveraging widely available dialysis platforms to enable clinical adoption.
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Abbreviations
- ECCO2R:
-
Extracorporeal CO2 removal
- HRF:
-
Hypercapnic respiratory failure
- COPD:
-
Chronic obstructive pulmonary disease
- IMV:
-
Invasive mechanical ventilation
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Acknowledgments
We are deeply indebted to the dedication and hard work of Mr. Jayon Wang for his efforts in conducting benchtop and animal experiments and for advancing the progress of this work. We also thank Ms. Samantha Russman for her critical aid with the benchtop experiments and data analysis.
Funding
SPK was funded by NIH 5K08HL143342-02. Partial funding for this work was provided by the Maxwell Maxcare Science Foundation in an exploratory research grant.
Author Contributions
BYC and SPK conceptualized and designed the project. BYC designed and conducted benchtop experiments. BYC and SPK designed and conducted animal studies, collated and analyzed animal study results, and prepared the manuscript.
Competing interests
BYC and SPK are co-inventors on pending international patent application PCT/US2018/051370 that covers a combined dialysis and oxygenator approach to treating hypercarbic respiratory failure. BYC and SPK are advisors to an early stage start-up entity that is attempting to manufacture the devices described in this manuscript.
Data and materials availability
The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
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Chang, B.Y., Keller, S.P. Dual Carbon Dioxide Capture to Achieve Highly Efficient Ultra-Low Blood Flow Extracorporeal Carbon Dioxide Removal. Ann Biomed Eng 48, 1562–1572 (2020). https://doi.org/10.1007/s10439-020-02477-1
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DOI: https://doi.org/10.1007/s10439-020-02477-1