Abstract
Mitochondria are essential organelles of virtually all eukaryotic organisms. As they cannot be made de novo, they have to be inherited during cell division. In this review, we provide an overview on mitochondrial inheritance in Saccharomyces cerevisiae, a powerful model organism to study asymmetric cell division. Several processes have to be coordinated during mitochondrial inheritance: mitochondrial transport along the actin cytoskeleton into the emerging bud is powered by a myosin motor protein; cell cortex anchors retain a critical fraction of mitochondria in the mother cell and bud to ensure proper partitioning; and the quantity of mitochondria inherited by the bud is controlled during cell cycle progression. Asymmetric division of yeast cells produces rejuvenated daughter cells and aging mother cells that die after a finite number of cell divisions. We highlight the critical role of mitochondria in this process and discuss how asymmetric mitochondrial partitioning and cellular aging are connected.
Acknowledgments
This paper is dedicated to the memory of Walter Neupert, who has been an inspiring mentor and great collaborator to BW for 27 years. We thank Veronika Bartosch and Xenia Chelius for critically reading the manuscript and Moritz Mayer for providing the electron micrograph shown in Figure 1. Research in the authors’ lab is funded by Deutsche Forschungsgemeinschaft through grants WE 2714/5-2 and WE 2714/7-1 and Elitenetzwerk Bayern through the Biological Physics program.
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