Computational saturation mutagenesis to predict structural consequences of systematic mutations in the beta subunit of RNA polymerase in Mycobacterium leprae
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Graphical abstract
Keywords
Mutation Coolspots
Mycobacterium leprae
In-silico Saturation Mutagenesis
Thermodynamic stability
Rifampin
RNA Polymerase
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Present address: Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, University of London, London WC1E 7HX, UK.
© 2020 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.