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New therapeutic perspectives for IgA nephropathy in children

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Abstract

Childhood IgA nephropathy (cIgAN) differs from the adult by having an abrupt clinical onset, often presenting as an acute attack that can progress to a chronic phase. No treatment guidelines have been established for the treatment of cIgAN. Given the severity of acute attack in children, and the number of life-years at stake, pediatricians prescribe immunosuppression in addition to renin–angiotensin system blockade. Non-specific immunosuppressors, such as corticosteroids, have systemic toxic effects, and given recent therapeutic advances in adult glomerulonephritis, new tailored strategies should be expected for children. The mucosal immune system has been highlighted as a key player in IgAN pathogenesis, and several biomarkers have been identified with a direct role in pathogenesis. In this review, we discuss current studies of conventional and novel therapeutic approaches for cIgAN.

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Authors and Affiliations

  1. Université de Paris, Centre de Recherche sur l’inflammation, Laboratoire d’Excellence Inflamex, F-75018, Paris, France

    Alexandra Cambier, Patrick J. Gleeson, Héloise Flament, Marie-Bénédicte Le Stang & Renato C. Monteiro

  2. INSERM U1149, Paris, France

    Alexandra Cambier, Patrick J. Gleeson, Héloise Flament, Marie-Bénédicte Le Stang & Renato C. Monteiro

  3. CNRS ERL8252, Paris, France

    Alexandra Cambier, Patrick J. Gleeson, Héloise Flament, Marie-Bénédicte Le Stang & Renato C. Monteiro

  4. Service de Néphrologie Pédiatrique, hôpital Robert Debré, Assistance Publique de Paris, Paris, France

    Alexandra Cambier

  5. Service d’Immunologie, hôpital Bichat, Paris, France

    Héloise Flament & Renato C. Monteiro

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  1. Alexandra Cambier
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  2. Patrick J. Gleeson
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  3. Héloise Flament
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  4. Marie-Bénédicte Le Stang
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  5. Renato C. Monteiro
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Correspondence to Renato C. Monteiro.

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Cambier, A., Gleeson, P.J., Flament, H. et al. New therapeutic perspectives for IgA nephropathy in children. Pediatr Nephrol 36, 497–506 (2021). https://doi.org/10.1007/s00467-020-04475-w

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  • DOI: https://doi.org/10.1007/s00467-020-04475-w

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