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Centenarian longevity is positively correlated with IgE levels but negatively correlated with C3/C4 levels, abdominal obesity and metabolic syndrome

Cellular & Molecular Immunology volume 17, pages 1196–1197 (2020)Cite this article

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Centenarians have delayed or absent onset and interaction of age-related disturbances and might be a prototype of human longevity and successful aging.1 What are the factors and models of centenarian longevity? This issue has confused humans for thousands of years. Studies comparing centenarians and other oldest-old individuals could identify the factors related to centenarian longevity, and analysis of their relationships in these oldest-old individuals could improve the models of centenarian longevity.1 All these factors and models could be used to identify therapeutic targets for the prevention of age-related disturbances and the promotion of centenarian longevity.

Metabolic syndrome represents metabolic disturbance in the human body and has an increasing prevalence of 20–25% worldwide.2 An increasing prevalence of metabolic syndrome with age has been reported in up to 42.0% of elderly individuals in the United States.3 However, it remains unclear whether the prevalence of metabolic syndrome is further elevated in centenarians from China. The immune system is closely related to metabolic syndrome, which is therefore considered a chronic immune-related disease.4 However, controversial conclusions have been documented, and the relationships between metabolic syndrome and immune function need to be clarified by large-scale studies in different populations, including the oldest-old population.5 Moreover, assessing whether immunological markers and metabolic syndrome are the factors related to centenarian longevity and whether their relationships exist in the oldest-old population as a model of centenarian longevity are greatly needed and important.

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Acknowledgements

This work was supported by grants from the National Key R&D Program of China (2018YFC2000400), the National Natural Science Foundation of China (81900357, 81903392), the National S&T Resource Sharing service platform Project of China (YCZYPT[2018]07), the General Hospital of PLA Medical Big Data R&D Project (MBD2018030), the China Postdoctoral Science Foundation funded project (2019M650359), the National Geriatric Disease Clinical Medicine Research Center Project (NCRCG-PLAGH-2017-014), the Military Medical Science and Technology Youth Incubation Program (20QNPY110), the Sanya Medical and Health Science and Technology Innovation Project (2016YW21), the Sanya Institutional and Local Scientific and Technological Cooperation Project, the Military Medicine Youth Program of Chinese PLA General Hospital (QNF19069) and the Clinical Scientific Research Supporting Fund of Chinese PLA General Hospital (2017FC-CXYY-3009). The sponsors had no role in the design, conduct, interpretation, review, approval or control of this article.

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Authors and Affiliations

  1. Department of Geriatric Cardiology, Chinese People’s Liberation Army General Hospital, Beijing, 100853, China

    Shihui Fu & Yulong Li

  2. Department of Cardiology, Hainan Hospital of Chinese People’s Liberation Army General Hospital, Sanya, 572013, China

    Shihui Fu & Juelin Deng

  3. Central Laboratory, Hainan Hospital of Chinese People’s Liberation Army General Hospital, Sanya, 572013, China

    Fu Zhang, Fuxin Luan & Yali Zhao

  4. Department of Ultrasound, Hainan Hospital of Chinese People’s Liberation Army General Hospital, Sanya, 572013, China

    Faqin Lv

  5. Center for Healthy Aging and Development Studies, National School of Development, Peking University, Beijing, 100871, China

    Yao Yao

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  1. Shihui Fu
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Contributions

S.F., Y.L., F.Z., F.X.L., F.Q.L., J.D., Y.Z., and Y.Y. contributed to the study design, performed the data collection and analyses, and drafted the paper.

Corresponding authors

Correspondence to Yali Zhao or Yao Yao.

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The authors declare no competing interests.

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Fu, S., Li, Y., Zhang, F. et al. Centenarian longevity is positively correlated with IgE levels but negatively correlated with C3/C4 levels, abdominal obesity and metabolic syndrome. Cell Mol Immunol 17, 1196–1197 (2020). https://doi.org/10.1038/s41423-020-0386-y

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