Issue 26, 2020

Tuning coordination chemistry through the second sphere in designed metallocoiled coils

Abstract

The metal hydration state within a designed coiled coil can be progressively tuned across the full integer range (3 → 0 aqua ligands), by careful choice of a second sphere terminal residue, including the lesser used Trp. Potential implications include a four-fold change in MRI relaxivity when applied to lanthanide coiled coils.

Graphical abstract: Tuning coordination chemistry through the second sphere in designed metallocoiled coils

Supplementary files

Article information

Article type
Communication
Submitted
18 Oct 2019
Accepted
26 Feb 2020
First published
26 Feb 2020
This article is Open Access
Creative Commons BY license

Chem. Commun., 2020,56, 3729-3732

Tuning coordination chemistry through the second sphere in designed metallocoiled coils

L. N. Slope, M. G. Hill, C. F. Smith, P. Teare, F. J. de Cogan, M. M. Britton and A. F. A. Peacock, Chem. Commun., 2020, 56, 3729 DOI: 10.1039/C9CC08189E

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