Skip to main content
Log in

Impact of a bioactive drug coating on the biocompatibility of magnesium alloys

  • Materials for life sciences
  • Published:
Journal of Materials Science Aims and scope Submit manuscript

Abstract

Magnesium alloys are promising materials for biodegradable vascular stents because of their good biocompatibility and physical properties. The poly-β-hydroxybutyrate (PHB) coating with vascular endothelial growth factor and heparin was prepared on the surface of WE magnesium alloys by layer-by-layer self-assembly technique. In this study, the effects of magnesium alloys with bioactive drug coating on human umbilical vein endothelial cells (HUVECs) and blood compatibility were investigated. The results showed that magnesium alloys with bioactive drug coating could decrease platelet adhesion, platelet activation, hemolysis rate, fibrinogen adsorption and increase activated partial thromboplastin time, prothrombin time, dynamic clotting of magnesium alloys. In addition, magnesium alloys with bioactive drug coating did not alter cytoskeleton morphological features of HUVECs, promoted cell adhesion and cell growth, and inhibited cell apoptosis. Therefore, the magnesium alloys with bioactive drug coating can be considered as potential and degradable biomaterials for vascular stents.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
Figure 11
Figure 12
Figure 13
Figure 14

Similar content being viewed by others

References

  1. Abdal-hay A, Dewidar M, Lim J, Lim JK (2014) Ceram Int 40:2237. https://doi.org/10.1016/j.ceramint.2013.07.142

    Article  CAS  Google Scholar 

  2. Abdal-hay A, Amna T, Lim JK (2013) Solid State Sci 18:131. https://doi.org/10.1016/j.solidstatesciences.2012.11.017

    Article  CAS  Google Scholar 

  3. Adhikari U, Rijal NP, Khanal S, Pai D, Sankar J, Bhattarai N (2016) Bioact Mater 1:132. https://doi.org/10.1016/j.bioactmat.2016.11.003

    Article  Google Scholar 

  4. Agarwal S, Curtin J, Duffy B, Jaiswal S (2016) Mater Sci Eng C-Mater Biol Appl 68:948. https://doi.org/10.1016/j.msec.2016.06.020

    Article  CAS  Google Scholar 

  5. Chen J, Tan L, Yu X, Etim IP, Ibrahim M, Yang K (2018) J Mech Behav Biomed Mater 87:68. https://doi.org/10.1016/j.jmbbm.2018.07.022

    Article  CAS  Google Scholar 

  6. Echeverry-Rendon M, Allain JP, Robledo SM, Echeverria F, Harmsen MC (2019) Mater Sci Eng C-Mater Biol Appl 102:150. https://doi.org/10.1016/j.msec.2019.04.032

    Article  CAS  Google Scholar 

  7. Argarate N, Olalde B, Atorrasagasti G et al (2014) Mater Lett 132:193. https://doi.org/10.1016/j.matlet.2014.06.070

    Article  CAS  Google Scholar 

  8. Bakhsheshi-Rad HR, Hamzah E, Kasiri-Asgarani M, Jabbarzare S, Iqbal N, Kadir MRA (2016) Mater Sci Eng C-Mater Biol Appl 60:526. https://doi.org/10.1016/j.msec.2015.11.057

    Article  CAS  Google Scholar 

  9. Cordoba LC, Marques A, Taryba M, Coradin T, Montemor F (2018) Surf Coat Technol 341:103. https://doi.org/10.1016/j.surfcoat.2017.08.062

    Article  CAS  Google Scholar 

  10. Cui LY, Fang XH, Cao W et al (2018) Appl Surf Sci 457:49. https://doi.org/10.1016/j.apsusc.2018.06.240

    Article  CAS  Google Scholar 

  11. Celarek A, Kraus T, Tschegg EK et al (2012) Mater Sci Eng C-Mater Biol Appl 32:1503. https://doi.org/10.1016/j.msec.2012.04.032

    Article  CAS  Google Scholar 

  12. Miller ND, Williams DF (1987) Biomaterials 8:129. https://doi.org/10.1016/0142-9612(87)90102-5

    Article  CAS  Google Scholar 

  13. Raza ZA, Riaz S, Banat IM (2018) Biotechnol Prog 34:29. https://doi.org/10.1002/btpr.2565

    Article  CAS  Google Scholar 

  14. Jin S, Gu H, Chen XS et al (2018) Colloid Surf. B-Biointerfaces 167:28. https://doi.org/10.1016/j.colsurfb.2018.03.047

    Article  CAS  Google Scholar 

  15. Zhao Q, Mahmood W, Zhu YY (2016) Appl Surf Sci 367:249. https://doi.org/10.1016/j.apsusc.2016.01.055

    Article  CAS  Google Scholar 

  16. Ruttala HB, Ramasamy T, Shin BS, Choi HG, Yong CS, Kim JO (2017) Int J Pharm 519:11. https://doi.org/10.1016/j.ijpharm.2017.01.011

    Article  CAS  Google Scholar 

  17. Abdelwahab MA, El-Barbary AA, El-Said KS, El Naggar SA, ElKholy HM (2019) Int J Biol Macromol 122:793. https://doi.org/10.1016/j.ijbiomac.2018.10.164

    Article  CAS  Google Scholar 

  18. Yang H, Qu X, Lin W, Wang C et al (2018) Acta Biomater 71:200–214

    Article  CAS  Google Scholar 

  19. Gu X, Zheng Y, Cheng Y et al (2009) Biomaterials 30:484

    Article  CAS  Google Scholar 

  20. Lee JY, Schmidt C (2015) J Biomed Mater Res Part A 103:2126

    Article  CAS  Google Scholar 

  21. Venault A, Hsu K-J, Yeh L-C et al (2017) Colloids Surf B Biointerfaces 151:372

    Article  CAS  Google Scholar 

  22. Chen HY, Zhang EL, Yang K (2014) Mater Sci Eng C-Mater Biol Appl 34:201. https://doi.org/10.1016/j.msec.2013.09.010

    Article  CAS  Google Scholar 

  23. Goosen MFA, Sefton MV (1983) J Biomed Mater Res 17:359

    Article  Google Scholar 

  24. Liu Y, Zhang J, Wang J et al (2015) J Biomed Mater Res Part A 103:2024. https://doi.org/10.1002/jbm.a.35339

    Article  CAS  Google Scholar 

  25. Zhu S-J, Liu Q, Qian Y-F et al (2014) Front Mater Sci 8:256. https://doi.org/10.1007/s11706-014-0259-3

    Article  Google Scholar 

  26. Zou YH, Zeng RC, Wang QZ et al (2016) Front Mater Sci 10:281. https://doi.org/10.1007/s11706-016-0345-9

    Article  Google Scholar 

  27. Riaz A, Khan RA, Mirza T, Mustansir T, Ahmed M (2014) Pak J Pharm Sci 27:907

    Google Scholar 

  28. Lehle K, Gessner A, Wehner D, Schmid T, Wendel HP, Schmid C (2015) Transpl Int 28:42

    Article  Google Scholar 

  29. Lin WC, Liu TY, Yang MCJB (2004) Biomaterials 25:1947

    Article  CAS  Google Scholar 

  30. McDonald SM, Matheson LA, McBane JE et al (2011) J Cell Biochem 112:3762. https://doi.org/10.1002/jcb.23307

    Article  CAS  Google Scholar 

  31. McBane JE, Ebadi D, Sharifpoor S, Labow RS, Santerre JP (2011) Acta Biomater 7:115. https://doi.org/10.1016/j.actbio.2010.08.014

    Article  CAS  Google Scholar 

  32. McGuigan AP, Sefton MV (2007) Biomaterials 28:2547. https://doi.org/10.1016/j.biomaterials.2007.01.039

    Article  CAS  Google Scholar 

  33. McBane JE, Matheson LA, Sharifpoor S, Santerre JP, Labow RS (2009) Biomaterials 30:5497. https://doi.org/10.1016/j.biomaterials.2009.07.010

    Article  CAS  Google Scholar 

  34. Brockman KS, Kizhakkedathu JN, Santerre JP (2017) Acta Biomater 48:368. https://doi.org/10.1016/j.actbio.2016.11.005

    Article  CAS  Google Scholar 

  35. Zhang XY, Zhang GN, Zhang HY, Li JF, Yao XH, Tang B (2018) Colloid Surf B-Biointerfaces 172:338. https://doi.org/10.1016/j.colsurfb.2018.08.060

    Article  CAS  Google Scholar 

  36. Sadowski R, Gadzala-Kopciuch R, Buszewski B (2019) Curr Med Chem 26:166. https://doi.org/10.2174/0929867324666171005114150

    Article  CAS  Google Scholar 

  37. Khanna V, Shahzad A, Thayalasamy K et al (2018) Thromb Res 172:36. https://doi.org/10.1016/j.thromres.2018.09.062

    Article  CAS  Google Scholar 

  38. Dunne E, O’Halloran M, Porter E et al (2019) IEEE Trans Dielectr Electr Insul 26:229. https://doi.org/10.1109/tdei.2018.007508

    Article  CAS  Google Scholar 

  39. Yuan Y, Liu C, Yin M (2008) J Mater Sci-Mater Med 19:2187. https://doi.org/10.1007/s10856-007-3319-8

    Article  CAS  Google Scholar 

  40. Wang HG, Yin TY, Ge SP et al (2013) J Biomed Mater Res Part A 101:413. https://doi.org/10.1002/jbm.a.34339

    Article  CAS  Google Scholar 

  41. Ledda M, De Bonis A, Bertani FR et al (2015) Biomed Mater 10:7. https://doi.org/10.1088/1748-6041/10/3/035005

    Article  CAS  Google Scholar 

  42. Lin X, Tan L, Wang Q, Zhang G, Zhang B, Yang K (2013) Mater Sci Eng C-Mater Biol Appl 33:3881. https://doi.org/10.1016/j.msec.2013.05.023

    Article  CAS  Google Scholar 

  43. Nasiri M, Hassanzadeh-Tabrizi SA (2018) J Chin Chem Soc 65:231. https://doi.org/10.1002/jccs.201700271

    Article  CAS  Google Scholar 

  44. Tanasie G, Bojin F, Tatu RF et al (2017) Mater Plast 54:523

    Article  Google Scholar 

  45. Barrowcliffe TW (2012) In: Lever R, Mulloy B, Page CP (eds) Heparin - A century of progress. Handbook of experimental pharmacology, vol 207. Springer, Berlin, Heidelberg

  46. Onishi A, St Ange K, Dordick JS, Linhardt RJ (2016) Front Biosci 21:1372

    Article  CAS  Google Scholar 

  47. Zhang H, Jia X, Han F et al (2013) Biomaterials 34:2202

    Article  CAS  Google Scholar 

  48. Heinolainen K, Karaman S, Amico GD et al (2017) Circ Res J Am Heart 120:1414

    Article  CAS  Google Scholar 

  49. Li H, Peng F, Wang D, Qiao Y, Xu D, Liu X (2018) Biomater Sci 6:1846

    Article  CAS  Google Scholar 

  50. Liu T, Zeng Z, Liu Y et al (2014) ACS Appl Mater Interfaces 6:8729. https://doi.org/10.1021/am5015309

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was partially supported by the NSFC 31700826. This work was also financially supported by Chongqing Research Program of Basic Research and Frontier Technology (cstc2017jcyjAX0284) and the Visiting Scholar Foundation of Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education (CQKLBST-2016-001).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ge Shuping.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Liang, Q., Shuping, G., Chenyu, L. et al. Impact of a bioactive drug coating on the biocompatibility of magnesium alloys. J Mater Sci 55, 6051–6064 (2020). https://doi.org/10.1007/s10853-020-04365-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10853-020-04365-4

Navigation