Elsevier

Kidney International

Volume 97, Issue 3, March 2020, Pages 450-452
Kidney International

Commentary
Dysfunctional HDL takes its Toll on the endothelial glycocalyx

https://doi.org/10.1016/j.kint.2019.11.017Get rights and content
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Patients with end-stage renal disease have a high risk of dying from cardiovascular disease that cannot be explained solely by traditional cardiovascular disease risk factors. Hesse et al. suggest that dysfunctional high-density lipoprotein cholesterol generated in patients with end-stage renal disease causes endothelial glycocalyx degradation. Glycocalyx degradation may represent one of the earliest insults leading to atheroma formation, and so this work suggests a novel link between renal failure and cardiovascular disease.

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see basic research on page 502