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GPR84: an immune response dial?

  1. Megan L. Wojciechowicz

    1. Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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  2. Avi Ma’ayan

    1. Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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GPR84 is an understudied Gi-coupled G-protein-coupled receptor (GPCR) that is expressed on the surface of immune cells. Recently, the synthesis and discovery of chemical agonists and antagonists have begun to reveal the role of GPR84 in modulating the innate immune response in conditions such as fibrotic disorders and highlighted its potential as a drug target.

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Nature Reviews Drug Discovery 19, 374 (2020)

doi: https://doi.org/10.1038/d41573-020-00029-9

Acknowledgements

This article is part of a series from the NIH Common Fund Illuminating the Druggable Genome (IDG) programme. The goal of IDG is to catalyse research on understudied proteins from druggable gene families by providing reagents, phenotypes and a mineable database; focusing on GPCRs, kinases and ion channels. For more information, see https://druggablegenome.net/

Updates & Corrections

  • Correction 25 February 2020: The article has been corrected to also include GLPG1205, a GPR84 antagonist that is in a phase II trial for idiopathic pulmonary fibrosis.

Competing Interests

The authors declare no competing interests.

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