Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cancer genomics

One size does not fit all for mutational signatures

Nature Cancer volume 1, pages 158–159 (2020)Cite this article

Subjects

An Author Correction to this article was published on 18 March 2020

This article has been updated

Discerning and analyzing the mutational patterns that arise in the cancer genome can provide essential information on the process of tumorigenesis. An analytical framework and web-based tool now aim to aid in mutational signature assignment for improved tumor stratification.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Tissue type–specific mutational signatures.

Change history

References

  1. Stratton, M. R., Campbell, P. J. & Futreal, P. A. Nature 458, 719–724 (2009).

    Article  CAS  Google Scholar 

  2. Helleday, T., Eshtad, S. & Nik-Zainal, S. Nat. Rev. Genet. 15, 585–598 (2014).

    Article  CAS  Google Scholar 

  3. Alexandrov, L. B. et al. Nature 500, 415–421 (2013).

    Article  CAS  Google Scholar 

  4. Baez-Ortega, A. & Gori, K. Brief. Bioinform. 20, 77–88 (2019).

    Article  CAS  Google Scholar 

  5. Alexandrov, L. B. et al. bioRxiv https://doi.org/10.1101/322859 (2019).

  6. Nik-Zainal, S. et al. Cell 149, 979–993 (2012).

    Article  CAS  Google Scholar 

  7. Pich, O. et al. Nat. Genet. 51, 1732–1740 (2019).

    Article  CAS  Google Scholar 

  8. Petljak, M. et al. Cell 176, 1282–1294.e20 (2019).

    Article  CAS  Google Scholar 

  9. Rosenthal, R., McGranahan, N., Herrero, J., Taylor, B. S. & Swanton, C. Genome Biol. 17, 31 (2016).

    Article  Google Scholar 

  10. Blokzijl, F., Janssen, R., van Boxtel, R. & Cuppen, E. Genome Med. 10, 33 (2018).

    Article  Google Scholar 

  11. Degasperi, A. et al. Nat. Cancer https://doi.org/10.1038/s43018-020-0027-5 (2020).

  12. Schneider, G., Schmidt-Supprian, M., Rad, R. & Saur, D. Nat. Rev. Cancer 17, 239–253 (2017).

    Article  CAS  Google Scholar 

  13. Davies, H. et al. Nat. Med. 23, 517–525 (2017).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Computational Biology, University of Lausanne, Lausanne, Switzerland

    Giovanni Ciriello

  2. Swiss Cancer Center Léman, Lausanne, Switzerland

    Giovanni Ciriello

  3. Swiss Institute of Bioinformatics, Lausanne, Switzerland

    Giovanni Ciriello

Authors
  1. Giovanni Ciriello
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Giovanni Ciriello.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ciriello, G. One size does not fit all for mutational signatures. Nat Cancer 1, 158–159 (2020). https://doi.org/10.1038/s43018-020-0033-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s43018-020-0033-7

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer