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TUMOR IMMUNOLOGY

CD36 — the Achilles’ heel of Treg cells

Nature Immunology volume 21, pages 251–253 (2020)Cite this article

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Regulatory T (Treg) cells suppress antitumor immunity, but Treg cell inhibition has been hampered by a lack of specific targets. CD36 expression by tumor-infiltrating Treg cells may provide a way to specifically target Treg cells in tumors.

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Fig. 1: Treg cells suppress effector T cells in the tumor microenvironment and in healthy tissues.

References

  1. Horton, B. L. et al. Cancer Immunol. Res. 6, 14–24 (2018).

    Article  CAS  Google Scholar 

  2. Wang, H. et al. Nat. Immunol. https://doi.org/10.1038/s41590-019-0589-5 (2020).

  3. Jansen, C. S. et al. Nature 576, 465–470 (2019).

    Article  CAS  Google Scholar 

  4. Spranger, S. et al. Sci. Transl. Med. 5, 200ra116 (2013).

    Article  Google Scholar 

  5. Bos, P. D. et al. J. Exp. Med. 210, 2435–2466 (2013).

    Article  Google Scholar 

  6. Sakaguchi, S. et al. J. Immunol. 155, 1151–1164 (1995).

    CAS  PubMed  Google Scholar 

  7. Simpson, T. R. et al. J. Exp. Med. 210, 1695–1710 (2013).

    Article  CAS  Google Scholar 

  8. Sharma, A. et al. Clin. Cancer Res. 25, 1233–1238 (2019).

    Article  Google Scholar 

  9. Kim, J. M., Rasmussen, J. P. & Rudensky, A. Y. Nat. Immunol. 8, 191–197 (2007).

    Article  CAS  Google Scholar 

  10. Wildin, R. S. et al. Nat. Genet. 27, 18–20 (2001).

    Article  CAS  Google Scholar 

  11. Maj, T. et al. Nat. Immunol. 18, 1332–1341 (2017).

    Article  CAS  Google Scholar 

  12. Field, C. S. et al. Cell Metab. https://doi.org/10.1016/j.cmet.2019.11.021 (2019).

    Article  Google Scholar 

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Authors and Affiliations

  1. Koch Institute for Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA

    Brendan L. Horton & Stefani Spranger

  2. Biology Department, Massachusetts Institute of Technology, Cambridge, MA, USA

    Stefani Spranger

  3. Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA

    Stefani Spranger

Authors
  1. Brendan L. Horton
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  2. Stefani Spranger
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Correspondence to Stefani Spranger.

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The authors declare no competing interests.

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Horton, B.L., Spranger, S. CD36 — the Achilles’ heel of Treg cells. Nat Immunol 21, 251–253 (2020). https://doi.org/10.1038/s41590-020-0601-0

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