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Continuous photocatalyzed aerobic oxidation of benzylic organotrifluoroborates to benzaldehydes under Taylor flow conditions

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Abstract

A simple continuous flow process for aerobic oxidation of benzylic organotrifluoroborates salt by photoredox catalysis under UV irradiation is reported. Using this approach benzylic organotrifluoroborates salts could be easily oxidized to the corresponding benzaldehydes. Good to excellent yields were obtained by applying short residence times in combination with molecular oxygen as oxidant under Taylor flow configuration.

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Acknowledgements

The authors gratefully acknowledge the CNRS and ANR JCJC 2019 “FLORyn” (191364) for the financial support. The authors thank Christophe Penverne who prepared the experimental setup.

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Authors and Affiliations

  1. Univ. Lille, CNRS, USR 3290 - MSAP - Miniaturisation pour la Synthèse, l’Analyse et la Protéomique, F-59000, Lille, France

    Mélanie Roseau, Nesrine Dhaouadi, Christian Rolando, Laëtitia Chausset-Boissarie & Maël Penhoat

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  1. Mélanie Roseau
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  2. Nesrine Dhaouadi
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  3. Christian Rolando
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  4. Laëtitia Chausset-Boissarie
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  5. Maël Penhoat
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Correspondence to Laëtitia Chausset-Boissarie.

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Roseau, M., Dhaouadi, N., Rolando, C. et al. Continuous photocatalyzed aerobic oxidation of benzylic organotrifluoroborates to benzaldehydes under Taylor flow conditions. J Flow Chem 10, 347–352 (2020). https://doi.org/10.1007/s41981-019-00053-w

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  • DOI: https://doi.org/10.1007/s41981-019-00053-w

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