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RETRACTED ARTICLE: A miR-1275 mimic protects myocardiocyte apoptosis by regulating the Wnt/NF-κB pathway in a rat model of myocardial ischemia–reperfusion-induced myocardial injury

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Abstract

This study evaluated the cardioprotective effects of a miR-1275 mimic in a rat model of myocardial ischemia–reperfusion (I/R)-induced myocardial injury (MI). Three groups of rats were established: a sham-operated group, a MI group and a MI+miR-1275 group pretreated for 1 week i.p. with a miR-1275 mimic at a concentration of 30 pmol/mL. MI was induced by I/R. The levels of myocardial enzymes in serum were estimated in all rats, together with haemodynamic functions. The effects of the miR-1275 mimic were determined based on the serum concentrations of inflammatory mediators in the treated vs. sham and MI rats. In addition, western blot assay and immunohistochemical analyses were performed to examine the effect of the miR-1275 mimic on the Wnt/NF-kB signalling pathway in MI rats. Treatment with the miR-1275 mimic attenuated the altered levels of myocardial enzymes and haemodynamic functions seen in MI rats. The myocardial infarct was smaller in rats treated with the miR-1275 mimic than in MI rats. The miR-1275 mimic also reduced myocardiocyte apoptosis and ameliorated the altered Wnt/KF-kB pathway. These results demonstrate the efficacy of the miR-1275 mimic in preventing myocardial I/R-induced MI in rats, by regulating the Wnt/NF-κB pathway.

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Acknowledgements

The authors thank the China–Japan Union Hospital of Jilin University, China, for providing the necessary facility to conduct this study.

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Author notes

  1. Tiechao Jiang and Hong You have equally contributed to this article.

Authors and Affiliations

  1. Department of Cardiovascular Medicine, China-Japan Union Hospital of Jilin University, Changchun, 130033, China

    Tiechao Jiang & Mei Ding

  2. Jilin Provincial Precision Medicine Key Laboratory for Cardiovascular Genetic Diagnosis, Changchun, 130033, China

    Tiechao Jiang & Mei Ding

  3. Department of Neurosurgery, The First Hospital of Jilin University, Changchun, 130021, China

    Hong You

  4. Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, 130021, China

    Dong You

  5. Depatment of Pathology, China-Japan Union Hospital of Jilin University, Changchun, 130033, China

    Lirong Zhang

  6. Department of Breast Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130033, China

    Bin Yang

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  1. Tiechao Jiang
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  2. Hong You
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  3. Dong You
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Correspondence to Mei Ding.

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This article has been retracted. Please see the retraction notice for more detail:https://doi.org/10.1007/s11010-022-04547-5

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Jiang, T., You, H., You, D. et al. RETRACTED ARTICLE: A miR-1275 mimic protects myocardiocyte apoptosis by regulating the Wnt/NF-κB pathway in a rat model of myocardial ischemia–reperfusion-induced myocardial injury. Mol Cell Biochem 466, 129–137 (2020). https://doi.org/10.1007/s11010-020-03695-w

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  • DOI: https://doi.org/10.1007/s11010-020-03695-w

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